(provided by candidate): CANDIDATE: Paul K. Crane, MD, is currently an NRSA Postdoctoral Fellow at the University of Washington in the Department of Internal Medicine. His long-term interest in measurement has developed into a specific interest in modern psychometric methods as they can be applied to the measurement of cognitive functioning in the elderly. ENVIRONMENT: The University of Washington represents an ideal environment for Dr. Crane's training and for the research he proposes. World-renowned clinical, epidemiological, and biostatistical expertise related to Alzheimer's Disease are available to support the development of Dr. Crane's research career. RESEARCH: Dr. Crane hypothesizes that recent advances in psychometric theory will have important benefits when applied to the measurement of cognitive function in the elderly. Every clinical and epidemiological study of dementia uses one or more tests of cognitive function. The importance of valid, precise, and unbiased assessment of cognitive function is difficult to overstate. Dr. Crane will explore and demonstrate the utility of advances in psychometric theory by evaluating existing data from several large data sets. These studies will provide pilot data for future applications, will establish an investigative pathway for Dr. Crane's future academic research career, and will likely lead to significant advances in thinking about measuring cognitive function.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Clinical Investigator Award (CIA) (K08)
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Special Emphasis Panel (ZAG1-ZIJ-1 (J3))
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Phelps, Creighton H
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University of Washington
Internal Medicine/Medicine
Schools of Medicine
United States
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Gibbons, Laura E; Crane, Paul K; Mehta, Kala M et al. (2011) Multiple, correlated covariates associated with differential item functioning (DIF): Accounting for language DIF when education levels differ across languages. Ageing Res 2:19-25
Crane, Paul K; Narasimhalu, Kaavya; Gibbons, Laura E et al. (2008) Composite scores for executive function items: demographic heterogeneity and relationships with quantitative magnetic resonance imaging. J Int Neuropsychol Soc 14:746-59
Crane, Paul K; Narasimhalu, Kaavya; Gibbons, Laura E et al. (2008) Item response theory facilitated cocalibrating cognitive tests and reduced bias in estimated rates of decline. J Clin Epidemiol 61:1018-27.e9
Crane, Paul K; Gibbons, Laura E; Ocepek-Welikson, Katja et al. (2007) A comparison of three sets of criteria for determining the presence of differential item functioning using ordinal logistic regression. Qual Life Res 16 Suppl 1:69-84
Crane, Paul K; Gibbons, Laura E; Jolley, Lance et al. (2006) Differential item functioning analysis with ordinal logistic regression techniques. DIFdetect and difwithpar. Med Care 44:S115-23
Crane, Heidi M; Kadane, Joseph B; Crane, Paul K et al. (2006) Diabetes case identification methods applied to electronic medical record systems: their use in HIV-infected patients. Curr HIV Res 4:97-106
Hart, Dennis L; Cook, Karon F; Mioduski, Jerome E et al. (2006) Simulated computerized adaptive test for patients with shoulder impairments was efficient and produced valid measures of function. J Clin Epidemiol 59:290-8
Crane, Paul K; Gibbons, Laura E; Jolley, Lance et al. (2006) Differential item functioning related to education and age in the Italian version of the Mini-mental State Examination. Int Psychogeriatr 18:505-15
Crane, Paul K; Hart, Dennis L; Gibbons, Laura E et al. (2006) A 37-item shoulder functional status item pool had negligible differential item functioning. J Clin Epidemiol 59:478-84
Wang, Li; van Belle, Gerald; Crane, Paul K et al. (2004) Subjective memory deterioration and future dementia in people aged 65 and older. J Am Geriatr Soc 52:2045-51

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