Abstract

The candidate proposes an extensive program to determine the role of cellular peri-kappa B in the pathogenesis of HIV-2 in monocytes. Specifically, she will: 1) purify and clone the peri-kappa B factor and characterize its binding to the HIV-2 enhancer; 2) identify possible interactions of the peri-kappa B factor with other cellular factors in activating HIV-2 transcription; and 3) determine the role of the peri- kappa B factor in HIV-replication.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AI001293-02
Application #
2057559
Study Section
Special Emphasis Panel (SRC (61))
Project Start
1994-09-30
Project End
1997-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Smith, M J; Gitlin, S D; Browning, C M et al. (2001) GLI-2 modulates retroviral gene expression. J Virol 75:2301-13
Browning, C M; Smith, M J; Clark, N M et al. (2001) Human GLI-2 is a tat activation response element-independent Tat cofactor. J Virol 75:2314-23
Clark, N M (1999) Paecilomyces lilacinus infection in a heart transplant recipient and successful treatment with terbinafine. Clin Infect Dis 28:1169-70
Clark, N M; Dieng Sarr, A; Sankale, J L et al. (1998) Immunologic and virologic response of HIV-2 infection to antiretroviral therapy. AIDS 12:2506-7
Clark, N M; Hannibal, M C; Markovitz, D M (1995) The peri-kappa B site mediates human immunodeficiency virus type 2 enhancer activation in monocytes but not in T cells. J Virol 69:4854-62