Regulation of Complement Activation by Vaccinia Virus

Isaacs, Stuart N.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Clinical Investigator Award (CIA) (K08)
• Project #: 5K08AI001324-02
• Application #: 2057615
• Study Section: Microbiology and Infectious Diseases B Subcommittee (MID)
• Project Start: 1995-09-01
• Project End: 1998-08-31
• Budget Start: 1996-09-01
• Budget End: 1997-08-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: University of Pennsylvania
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 042250712
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19104

Publications

Lorenzo, M M; Herrera, E; Blasco, R et al. (1998) Functional analysis of vaccinia virus B5R protein: role of the cytoplasmic tail. Virology 252:450-7

Sahu, A; Isaacs, S N; Soulika, A M et al. (1998) Interaction of vaccinia virus complement control protein with human complement proteins: factor I-mediated degradation of C3b to iC3b1 inactivates the alternative complement pathway. J Immunol 160:5596-604

Herrera, E; Lorenzo, M M; Blasco, R et al. (1998) Functional analysis of vaccinia virus B5R protein: essential role in virus envelopment is independent of a large portion of the extracellular domain. J Virol 72:294-302