Dr. Dan Barouch received his D.Phil. from Oxford University prior to completing his M.D. at Harvard Medical School. He is currently in his final year of internal medicine residency training at Massachusetts General Hospital, after which he will be a fellow in infectious diseases. He plans a full-time career as an academic investigator with a special interest in translational research and AIDS vaccine development. During medical school and residency, Dr. Barouch worked part-time in the laboratory of Dr. Norman Letvin at the Beth Israel Deaconess Medical Center. His preliminary work showed that cytokine plasmids could augment DNA vaccine- elicited immune responses in both mice and rhesus monkeys. Moreover, he demonstrated that cytokine-augmented DNA vaccination could control viremia and prevent clinical AIDS following a pathogenic, homologous SHIV challenge. In the current studies, he will examine the immune correlates of long-term control of viremia in these animals. He will also examine the protective efficacy of cytokine-augmented DNA vaccination strategies and DNA/rMVA (recombinant modified vaccinia Ankara) prime-boost regimens against pathogenic, heterologous viral challenges. In addition, he will initiate a phase I clinical trial to assess the safety, tolerability, and immunogenicity of cytokine-augmented DNA vaccine strategies in humans. Dr. Norman Letvin, Chief of the Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, and Dr. Raphael Dolin, Dean for Clinical Programs, Harvard Medical School, will guide Dr. Barouch's development as an independent investigator. In addition, a committee of distinguished scientists will oversee his progress toward independence.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AI051223-04
Application #
6897325
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Miller, Nancy R
Project Start
2002-07-01
Project End
2005-12-14
Budget Start
2005-07-01
Budget End
2005-12-14
Support Year
4
Fiscal Year
2005
Total Cost
$106,583
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
Barouch, Dan H (2006) Rational design of gene-based vaccines. J Pathol 208:283-9
Nanda, Anjali; Lynch, Diana M; Goudsmit, Jaap et al. (2005) Immunogenicity of recombinant fiber-chimeric adenovirus serotype 35 vector-based vaccines in mice and rhesus monkeys. J Virol 79:14161-8
Lemckert, Angelique A C; Sumida, Shawn M; Holterman, Lennart et al. (2005) Immunogenicity of heterologous prime-boost regimens involving recombinant adenovirus serotype 11 (Ad11) and Ad35 vaccine vectors in the presence of anti-ad5 immunity. J Virol 79:9694-701
Barouch, Dan H; Powers, Jennifer; Truitt, Diana M et al. (2005) Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants. Nat Immunol 6:247-52
Barouch, Dan H; Truitt, Diana M; Letvin, Norman L (2004) Expression kinetics of the interleukin-2/immunoglobulin (IL-2/Ig) plasmid cytokine adjuvant. Vaccine 22:3092-7
Sumida, Shawn M; McKay, Paul F; Truitt, Diana M et al. (2004) Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines. J Clin Invest 114:1334-42
McKay, Paul F; Barouch, Dan H; Santra, Sampa et al. (2004) Recruitment of different subsets of antigen-presenting cells selectively modulates DNA vaccine-elicited CD4+ and CD8+ T lymphocyte responses. Eur J Immunol 34:1011-20
Sumida, Shawn M; Truitt, Diana M; Kishko, Michael G et al. (2004) Neutralizing antibodies and CD8+ T lymphocytes both contribute to immunity to adenovirus serotype 5 vaccine vectors. J Virol 78:2666-73
Barouch, Dan H; Pau, Maria G; Custers, Jerome H H V et al. (2004) Immunogenicity of recombinant adenovirus serotype 35 vaccine in the presence of pre-existing anti-Ad5 immunity. J Immunol 172:6290-7
Barouch, Dan H; Kunstman, Jennifer; Glowczwskie, Jennifer et al. (2003) Viral escape from dominant simian immunodeficiency virus epitope-specific cytotoxic T lymphocytes in DNA-vaccinated rhesus monkeys. J Virol 77:7367-75

Showing the most recent 10 out of 11 publications