Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08AR001988-01
Application #
2077588
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1996-04-01
Project End
2001-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Moody, D Branch; Briken, Volker; Cheng, Tan-Yun et al. (2002) Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation. Nat Immunol 3:435-42
Gurcha, Sudagar S; Baulard, Alain R; Kremer, Laurent et al. (2002) Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis. Biochem J 365:441-50
Moody, D B; Besra, G S (2001) Glycolipid targets of CD1-mediated T-cell responses. Immunology 104:243-51
Moody, D B; Guy, M R; Grant, E et al. (2000) CD1b-mediated T cell recognition of a glycolipid antigen generated from mycobacterial lipid and host carbohydrate during infection. J Exp Med 192:965-76
Moody, D B; Reinhold, B B; Reinhold, V N et al. (1999) Uptake and processing of glycosylated mycolates for presentation to CD1b-restricted T cells. Immunol Lett 65:85-91
Jackman, R M; Moody, D B; Porcelli, S A (1999) Mechanisms of lipid antigen presentation by CD1. Crit Rev Immunol 19:49-63
Moody, D B; Besra, G S; Wilson, I A et al. (1999) The molecular basis of CD1-mediated presentation of lipid antigens. Immunol Rev 172:285-96
Jackman, R M; Stenger, S; Lee, A et al. (1998) The tyrosine-containing cytoplasmic tail of CD1b is essential for its efficient presentation of bacterial lipid antigens. Immunity 8:341-51
Moody, D B; Reinhold, B B; Guy, M R et al. (1997) Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. Science 278:283-6
Moody, D B; Sugita, M; Peters, P J et al. (1996) The CD1-restricted T-cell response to mycobacteria. Res Immunol 147:550-9