Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08CA001422-02
Application #
3079906
Study Section
Cancer Institutional Fellowship Review Committee (CT)
Project Start
1990-07-01
Project End
1995-06-30
Budget Start
1991-07-01
Budget End
1992-06-30
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Carroll, M; Ohno-Jones, S; Tamura, S et al. (1997) CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins. Blood 90:4947-52
Druker, B J; Tamura, S; Buchdunger, E et al. (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 2:561-6
Jain, S K; Susa, M; Keeler, M L et al. (1996) PI 3-kinase activation in BCR/abl-transformed hematopoietic cells does not require interaction of p85 SH2 domains with p210 BCR/abl. Blood 88:1542-50
Oda, T; Tamura, S; Matsuguchi, T et al. (1995) The SH2 domain of ABL is not required for factor-independent growth induced by BCR-ABL in a murine myeloid cell line. Leukemia 9:295-301
Carlesso, N; Griffin, J D; Druker, B J (1994) Use of a temperature-sensitive mutant to define the biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line. Oncogene 9:149-56
Oda, T; Heaney, C; Hagopian, J R et al. (1994) Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia. J Biol Chem 269:22925-8
Avalos, B R; Broudy, V C; Ceselski, S K et al. (1994) Abnormal response to granulocyte colony-stimulating factor (G-CSF) in canine cyclic hematopoiesis is not caused by altered G-CSF receptor expression. Blood 84:789-94
Druker, B J; Neumann, M; Okuda, K et al. (1994) rel Is rapidly tyrosine-phosphorylated following granulocyte-colony stimulating factor treatment of human neutrophils. J Biol Chem 269:5387-90
Epstein, R J; Druker, B J; Roberts, T M et al. (1992) Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor. Proc Natl Acad Sci U S A 89:10435-9
Druker, B J; Sibert, L; Roberts, T M (1992) Polyomavirus middle T-antigen NPTY mutants. J Virol 66:5770-6