Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
7K08CA001752-04
Application #
2084410
Study Section
Cancer Institutional Fellowship Review Committee (CT)
Project Start
1993-08-01
Project End
1997-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Byun, Y; Chen, F; Chang, R et al. (2001) Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis. Cell Death Differ 8:443-50
Bialik, S; Cryns, V L; Drincic, A et al. (1999) The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes. Circ Res 85:403-14
Cryns, V; Yuan, J (1998) Proteases to die for. Genes Dev 12:1551-70
Cryns, V L; Byun, Y; Rana, A et al. (1997) Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy. J Biol Chem 272:29449-53
Li, H; Bergeron, L; Cryns, V et al. (1997) Activation of caspase-2 in apoptosis. J Biol Chem 272:21010-7
Tahara, H; Smith, A P; Gas, R D et al. (1996) Genomic localization of novel candidate tumor suppressor gene loci in human parathyroid adenomas. Cancer Res 56:599-605
Cryns, V L; Bergeron, L; Zhu, H et al. (1996) Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease. J Biol Chem 271:31277-82
Carson, W E; Giri, J G; Lindemann, M J et al. (1994) Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 180:1395-403
Caligiuri, M A; Schichman, S A; Strout, M P et al. (1994) Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations. Cancer Res 54:370-3
Cryns, V L; Thor, A; Xu, H J et al. (1994) Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma. N Engl J Med 330:757-61

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