This is a career development grant proposal to enable Dr. Glen Morrell (the applicant) to develop a long term research program in the application of new methods of magnetic resonance imaging (MRI) of breast cancer. Dr. Morrell received a Ph.D. degree in Electrical Engineering from Stanford in 1998, researching novel methods for MRI. He then completed medical school at Stanford and a Diagnostic Radiology residency and fellowship in MRI at the University of Pennsylvania. He is now in his first year as Assistant Professor of Radiology at the University of Utah. His goal is to combine his knowledge of MRI physics and novel MRI techniques with the clinical practice of radiology, specifically in MRI of breast cancer. Despite the applicant's many years of education, he has had no postdoctoral training in electrical engineering, and has not had opportunity to apply techniques developed in his Ph.D. research to clinically relevant imaging problems. The requested support will allow Dr. Morrell to continue his education in aspects of physics and engineering related to medical imaging, and to continue to gain clinical expertise as a radiologist. During the five-year funding period, Dr. Morrell will apply techniques of multi-dimensional excitation from his Ph.D. research to improve breast MRI and validate these techniques through limited clinical trials. He will gain a greater understanding of quantum mechanics and other principles of physics directly relating to MRI with the aim of developing methods of spectroscopic imaging of the breast. He will be mentored in the design of clinical trials and the conduct of research. The expected benefit of the proposed research plan is improved detection of breast cancer and decreased number of invasive biopsies of benign breast lesions. Based on the pilot studies supported by this grant, Dr. Morrell will submit proposals for funding through R01 or similar mechanisms to maintain and expand a long term research program in MRI of breast cancer, collaborating with well established programs in oncology, pharmaceutics, and genetics at the University of Utah.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08CA112449-05
Application #
7667289
Study Section
Subcommittee G - Education (NCI)
Program Officer
Myrick, Dorkina C
Project Start
2005-08-19
Project End
2012-07-31
Budget Start
2009-08-01
Budget End
2012-07-31
Support Year
5
Fiscal Year
2009
Total Cost
$140,130
Indirect Cost
Name
University of Utah
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Hansen, Esben Szocska Søvsø; Kim, Sun; Miller, Jack J et al. (2016) Fast Padé Transform Accelerated CSI for Hyperpolarized MRS. Tomography 2:117-124
Morrell, Glen R; Ikizler, Talat A; Chen, Xiaorui et al. (2016) Psoas Muscle Cross-sectional Area as a Measure of Whole-body Lean Muscle Mass in Maintenance Hemodialysis Patients. J Ren Nutr 26:258-64
Kaggie, Joshua D; Hadley, J Rock; Badal, James et al. (2014) A 3 T sodium and proton composite array breast coil. Magn Reson Med 71:2231-42
Park, Daniel J; Bangerter, Neal K; Javed, Ahsan et al. (2013) A statistical analysis of the Bloch-Siegert B1 mapping technique. Phys Med Biol 58:5673-91
Wang, Yi; Morrell, Glen; Heibrun, Marta E et al. (2013) 3D multi-parametric breast MRI segmentation using hierarchical support vector machine with coil sensitivity correction. Acad Radiol 20:137-47
Quist, Brady; Hargreaves, Brian A; Cukur, Tolga et al. (2012) Simultaneous fat suppression and band reduction with large-angle multiple-acquisition balanced steady-state free precession. Magn Reson Med 67:1004-12
Allen, Steven P; Morrell, Glen R; Peterson, Brock et al. (2011) Phase-sensitive sodium B1 mapping. Magn Reson Med 65:1125-30
Gold, Garry E (2010) New frontiers in magnetic resonance imaging of joints. Top Magn Reson Imaging 21:273
Morrell, Glen R; Schabel, Matthias C (2010) An analysis of the accuracy of magnetic resonance flip angle measurement methods. Phys Med Biol 55:6157-74
Schabel, Matthias C; Morrell, Glen R; Oh, Karen Y et al. (2010) Pharmacokinetic mapping for lesion classification in dynamic breast MRI. J Magn Reson Imaging 31:1371-8

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