Mentored Clinical Scientist Development Award: The nominee, Catherine A. Martin, M.D., proposes to develop as an independent clinical researcher in the University of Kentucky Department of Psychiatry and the Center on Drug and Alcohol Research. Her research focus and the purpose of this study is to determine if drug use risk in adolescents with impulse disorders; e.g. Attention Deficit Hyperactivity Disorder (ADHD) and co-morbid Conduct Disorder (CD), is altered by pubertal hormonal changes. Measures of impulsivity, drug use and testosterone in males and testosterone and estradiol in females, will be obtained from 120 subjects at pre-, early and mid-adolescence, (ages 11 l/2 -12 1/2; 13-14; and 14 l/2 -15 1/'2). The overall hypothesis is that testosterone and estradiol increase impulsivity in an already at risk population. This increased impulsivity escalates risk for drug use. Ultimately, the long range goal of this study is to add to the knowledge base and the understanding of how pubertal hormonal changes in impulsive adolescents are related to risk for drug use. The nominee is an established clinician and medical educator with an ongoing investment, but no formal training in research. This award will allow the nominee to acquire the knowledge and experience to develop research paradigms involving at risk psychiatric populotions, particularly those with impulse disorders, and drug use. The nominee will use these skills to develop a drug research program on the course of drug use in children and adolescents with impulse disorders.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Clinical Investigator Award (CIA) (K08)
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Special Emphasis Panel (ZDA1-MXS-M (01))
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Borek, Nicolette T
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University of Kentucky
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Martin, Catherine A; Cook, Circe; Woodring, John H et al. (2008) Caffeine use: association with nicotine use, aggression, and other psychopathology in psychiatric and pediatric outpatient adolescents. ScientificWorldJournal 8:512-6
Martin, Catherine A; Guenthner, Greg; Bingcang, Christopher et al. (2007) Measurement of the subjective effects of methylphenidate in 11- to 15-year-old children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 17:63-73
Martin, C A; Lommel, K; Cox, J et al. (2007) Kiss and tell: what do we know about pre- and early adolescent females who report dating? A pilot study. J Pediatr Adolesc Gynecol 20:45-9
Martin, Catherine A; Guenthner, Greg; Bingcang, Christopher et al. (2006) A pilot study: attention deficit hyperactivity disorder, sensation seeking, and pubertal changes. ScientificWorldJournal 6:637-42
van de Venne, Judy; Bradford, Kay; Martin, Catherine et al. (2006) Depression, sensation seeking, and maternal smoking as predictors of adolescent cigarette smoking. ScientificWorldJournal 6:643-52
Martin, Catherine A; Kelly, Thomas H; Rayens, Mary Kay et al. (2004) Sensation seeking and symptoms of disruptive disorder: association with nicotine, alcohol, and marijuana use in early and mid-adolescence. Psychol Rep 94:1075-82
Martin, Catherine A; Kelly, Thomas H; Rayens, Mary Kay et al. (2002) Sensation seeking, puberty, and nicotine, alcohol, and marijuana use in adolescence. J Am Acad Child Adolesc Psychiatry 41:1495-502
Martin, C A; Logan, T K; Portis, C et al. (2001) The association of testosterone with nicotine use in young adult females. Addict Behav 26:279-83
Martin, C A; Rayens, M K; Kelly, T et al. (2000) Card Perseveration Task performance and post-task feeling states: relationship to drug use in adolescents. Am J Drug Alcohol Abuse 26:325-33
Martin, C A; Mainous 3rd, A G; Curry, T et al. (1999) Alcohol use in adolescent females: correlates with estradiol and testosterone. Am J Addict 8:9-14