Dr. McChargue's short-term goals are to enhance the theoretical, methodological, and statistical skills that he needs to study the determinants of nicotine self-administration in smokers with comorbid psycohpathology. His long-term goals are to develop an independent laboratory, as well as a network of research collaborators devoted to advancing our understanding of nicotine dependence and training fixture clinical researchers. The proposed studies will evaluate two premises about smokers with a history of depression that have been assumed but not directly tested. The first proposition is that depression-prone smokers experience greater than normal cigarette cravings when exposed to negative affect cues. The second proposition is that the dysphoria-reducing effects of self-administering nicotine are more potent for depression-prone than non-prone smokers. Study 1 aims to compare the reactivity of smokers with and without history of depression to cues involving smoking paraphernalia and negative mood. Reactivity will be measured via self-report, behavioral and physiological indices of craving. The hypothesis is that depression-prone smokers will show heightened cue reactivity in general, but will be especially reactive to dysphoric mood cues.
The aim of Study 2 is to compare the degree to which smoking a nicotinized versus a denicotinized cigarette alleviates experimentally induced dysphoria in smokers with versus without a history of depression. The hypothesis is that nicotine's potency as a negative reinforcer (i.e., its ability dispel dysphoric mood) will be enhanced for smokers who have a history of depression, as compared to those who lack such a history. These studies will be the first to systematically examine craving responses in depression-prone smokers and to quantify the dysphoria-reducing effects of nicotine administration for this population. Results should increase understanding of mechanisms that mediate the high prevalence and persistence of smoking among depression-prone individuals, and may contribute to the development of novel treatments for this recalcitrant group of smokers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08DA000467-03
Application #
6523135
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Schnur, Paul
Project Start
2000-09-10
Project End
2005-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
3
Fiscal Year
2002
Total Cost
$117,245
Indirect Cost
Name
University of Illinois at Chicago
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612
McChargue, Dennis E; Doran, Neal (2009) Cue-evoked positive affect, depression vulnerability and smoking years. Am J Health Behav 33:49-57
Klanecky, Alicia K; McChargue, Dennis E (2009) Emotional reactivity across individuals with varying trauma and substance dependence histories. Ment Health Subst Use 2:191-202
Pagoto, Sherry L; Spring, Bonnie; McChargue, Dennis et al. (2009) Acute tryptophan depletion and sweet food consumption by overweight adults. Eat Behav 10:36-41
McChargue, Dennis E; Klanecky, Alicia K; Walsh, Kate et al. (2008) Trauma exposure influences cue elicited affective responses among smokers with and without a history of major depression. Addict Behav 33:1454-62
Doran, Neal; McChargue, Dennis; Spring, Bonnie (2008) Effect of impulsivity on cardiovascular and subjective reactivity to smoking cues. Addict Behav 33:167-72
Spring, Bonnie; Hitsman, Brian; Pingitore, Regina et al. (2007) Effect of tryptophan depletion on smokers and nonsmokers with and without history of major depression. Biol Psychiatry 61:70-7
Doran, Neal; McChargue, Dennis; Cohen, Lee (2007) Impulsivity and the reinforcing value of cigarette smoking. Addict Behav 32:90-8
Doran, Neal; Spring, Bonnie; Borrelli, Belinda et al. (2006) Elevated positive mood: a mixed blessing for abstinence. Psychol Addict Behav 20:36-43
McChargue, Dennis E; Cohen, Lee M; Cook, Jessica W (2004) Attachment and depression differentially influence nicotine dependence among male and female undergraduates: a preliminary study. J Am Coll Health 53:5-10
McChargue, Dennis; Cohen, Lee; Cook, Jessica Werth (2004) The influence of personality and affect on nicotine dependence among male college students. Nicotine Tob Res 6:287-94

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