This application proposes five years of support to investigate the relationship between substance dependence, conduct disorder and certain genetic polymorphisms among Asian American adolescents. There is little research characterizing conduct disordered Asian American adolescents. General population estimates and the applicant's preliminary data suggest conduct disordered Asian American adolescents are a high-risk population for comorbid substance use disorders. Asians also have high prevalence of alleles that are known to affect alcohol and nicotine metabolism. Therefore, conduct disordered Asian American adolescents likely represent a genetically informative population regarding adolescent substance use disorders. The applicant proposes to collect a sample of Asian American adolescents with conduct disorder (n=100), Asian adolescent controls (n=200), and first-degree relatives of conduct disordered probands (n=162).
The aims i nclude 1) examining the relationship between conduct disorder and substance use disorders among Asian American adolescents, 2) testing whether substance dependence and conduct disorder are familial in Asian American families, and 3) testing whether ALDH and CYP2A6 genotypes are associated with alcohol and nicotine dependence. The proposed training includes 1) completion of formal coursework and workshops dealing with twin studies, genetic association and linkage studies, 2) mentored analyses of data already collected (DA11015), focusing on within and between family genetic association studies of adolescent substance use disorders, 3) mentored analyses of national data bases examining risk factors for substance dependence among Asian Americans, and 4) attendance at national meetings.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Clinical Investigator Award (CIA) (K08)
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Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Weinberg, Naimah Z
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University of Colorado Denver
Schools of Medicine
United States
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Sakai, Joseph T; Crowley, Thomas J; Stallings, Michael C et al. (2012) Test of association between 10 single nucleotide polymorphisms in the oxytocin receptor gene and conduct disorder. Psychiatr Genet 22:99-102
Sakai, Joseph T; Stallings, Michael C; Crowley, Thomas J et al. (2010) Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives. Drug Alcohol Depend 106:199-203
Sakai, Joseph T; Boardman, Jason D; Gelhorn, Heather L et al. (2010) Using trajectory analyses to refine phenotype for genetic association: conduct problems and the serotonin transporter (5HTTLPR). Psychiatr Genet 20:199-206
Sakai, Joseph T; Wang, Cynthia; Price, Rumi Kato (2010) Substance use and dependence among Native Hawaiians, Other Pacific Islanders, and Asian ethnic groups in the United States: contrasting multiple-race and single-race prevalence rates from a national survey. J Ethn Subst Abuse 9:173-85
Hartman, Christie A; Hopfer, Christian J; Haberstick, Brett et al. (2009) The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults. Drug Alcohol Depend 104:11-6
Gelhorn, Heather; Hartman, Christie; Sakai, Joseph et al. (2009) An item response theory analysis of DSM-IV conduct disorder. J Am Acad Child Adolesc Psychiatry 48:42-50
Hartman, Christie A; Gelhorn, Heather; Crowley, Thomas J et al. (2008) Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescents. J Am Acad Child Adolesc Psychiatry 47:165-73
Gelhorn, Heather; Hartman, Christie; Sakai, Joseph et al. (2008) Toward DSM-V: an item response theory analysis of the diagnostic process for DSM-IV alcohol abuse and dependence in adolescents. J Am Acad Child Adolesc Psychiatry 47:1329-39
Sakai, J T; Risk, N K; Tanaka, C A et al. (2008) Conduct disorder among Asians and Native Hawaiian/Pacific Islanders in the USA. Psychol Med 38:1013-25
Sakai, Joseph T; Hopfer, Christian J; Hartman, Christie et al. (2007) Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problems. Drug Alcohol Depend 88:130-7

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