The objectives of this research are: 1) to examine the articulatory and phonatory characteristics of two groups of dysarthric speakers; 2) determine how those characteristics of speech motor control change during disease progression or as a result of pharmacological intervention: and 3) determine the acoustic features that are associated with changes in intelligibility. To achieve these objectives, three projects are proposed during the five year award period. In Project 1, which is a group comparison of ALS speakers with varying degrees of intelligibility, acoustic analyses of word and sentence production and phonatory analyses of steady state phonation will be completed in order to provide a needed data base regarding the nature of the dysarthria in ALS at different degrees of disease severity. Project 2, a series of within subject longitudinal studies, will examine the effects of disease progression in ALS on speech intelligibility through the use of perceptual, acoustic and physiological methods. Project 3 is designed to examine, through acoustic and phonatory analyses, the articulatory and phonatory characteristics of the dysarthria accompanying myasthenia gravis and the effects of two types of pharmacological intervention in this subject group.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08DC000043-04
Application #
2124251
Study Section
Communication Disorders Review Committee (CDRC)
Project Start
1991-04-01
Project End
1996-03-31
Budget Start
1994-04-01
Budget End
1995-03-31
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Washington
Department
Other Health Professions
Type
Schools of Arts and Sciences
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Buder, Eugene H; Strand, Edythe A (2003) Quantitative and graphic acoustic analysis of phonatory modulations: the modulogram. J Speech Lang Hear Res 46:475-90
Strand, E A; Miller, R M; Yorkston, K M et al. (1996) Management of oral-pharyngeal dysphagia symptoms in amyotrophic lateral sclerosis. Dysphagia 11:129-39
Strand, E A; Buder, E H; Yorkston, K M et al. (1994) Differential phonatory characteristics of four women with amyotrophic lateral sclerosis. J Voice 8:327-39