The research will involve work on three projects which are at differing stages of development. The candidate will, as a result, be exposed to a broad range of activities in the field of structural research. Project one will extend the resolution of the complex of carboxypeptidase A with a protease inhibitor isolated from the potato, also attempt to capture, within the active site, the structure of an enzyme-inhibitor-product complex. Project two will attempt elucidation of the three dimensional structure of insulin complexed with monoclonal antibody. The goal of project three is crystallization of plasma apolipoproteins and their synthetic analogues for subsequent structure determination.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08DK001928-05
Application #
2133568
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1989-08-01
Project End
1995-06-30
Budget Start
1993-07-01
Budget End
1995-06-30
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030