Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08DK002119-05
Application #
2133844
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1992-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Ito, M; Grujic, D; Abel, E D et al. (1998) Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements. Diabetes 47:1464-71
Vidal-Puig, A; Solanes, G; Grujic, D et al. (1997) UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun 235:79-82
Lowell, B B; Flier, J S (1997) Brown adipose tissue, beta 3-adrenergic receptors, and obesity. Annu Rev Med 48:307-16
Grujic, D; Susulic, V S; Harper, M E et al. (1997) Beta3-adrenergic receptors on white and brown adipocytes mediate beta3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. A study using transgenic and gene knockout mice. J Biol Chem 272:17686-93
Solanes, G; Vidal-Puig, A; Grujic, D et al. (1997) The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. J Biol Chem 272:25433-6
Hollenberg, A N; Susulic, V S; Madura, J P et al. (1997) Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter. J Biol Chem 272:5283-90
Cinti, S; Frederich, R C; Zingaretti, M C et al. (1997) Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue. Endocrinology 138:797-804
Hamann, A; Flier, J S; Lowell, B B (1996) Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology 137:21-9
Mantzoros, C S; Qu, D; Frederich, R C et al. (1996) Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes 45:909-14
Hamann, A; Benecke, H; Le Marchand-Brustel, Y et al. (1995) Characterization of insulin resistance and NIDDM in transgenic mice with reduced brown fat. Diabetes 44:1266-73

Showing the most recent 10 out of 12 publications