Renal Epithelial Cell Response to Urea

Cohen, David M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Clinical Investigator Award (CIA) (K08)
• Project #: 5K08DK002188-05
• Application #: 2133980
• Study Section: Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
• Project Start: 1993-07-01
• Project End: 1998-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: Oregon Health and Science University
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 009584210
• City: Portland
• State: OR
• Country: United States
• Zip Code: 97239

Publications

Zhang, Z; Cohen, D M (1998) Urea activates ribosomal S6 kinase (RSK) in a MEK-dependent fashion in renal mIMCD3 cells. Am J Physiol 274:F73-8

Zhang, Z; Cohen, D M (1997) Hypotonicity increases transcription, expression, and action of Egr-1 in murine renal medullary mIMCD3 cells. Am J Physiol 273:F837-42

Cohen, D M; Gullans, S R; Chin, W W (1996) Urea inducibility of egr-1 in murine inner medullary collecting duct cells is mediated by the serum response element and adjacent Ets motifs. J Biol Chem 271:12903-8

Cohen, D M; Gullans, S R; Chin, W W (1996) Urea signaling in cultured murine inner medullary collecting duct (mIMCD3) cells involves protein kinase C, inositol 1,4,5-trisphosphate (IP3), and a putative receptor tyrosine kinase. J Clin Invest 97:1884-9

Cohen, D M (1996) Urea-inducible Egr-1 transcription in renal inner medullary collecting duct (mIMCD3) cells is mediated by extracellular signal-regulated kinase activation. Proc Natl Acad Sci U S A 93:11242-7

Cohen, D M; Chin, W W; Gullans, S R (1994) Hyperosmotic urea increases transcription and synthesis of Egr-1 in murine inner medullary collecting duct (mIMCD3) cells. J Biol Chem 269:25865-70