Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08DK002276-03
Application #
2134143
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1994-05-01
Project End
1996-09-30
Budget Start
1996-05-01
Budget End
1996-09-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Yamanaka, Y; Fowlkes, J L; Wilson, E M et al. (1999) Characterization of insulin-like growth factor binding protein-3 (IGFBP-3) binding to human breast cancer cells: kinetics of IGFBP-3 binding and identification of receptor binding domain on the IGFBP-3 molecule. Endocrinology 140:1319-28
Fowlkes, J L; Thrailkill, K M; George-Nascimento, C et al. (1997) Heparin-binding, highly basic regions within the thyroglobulin type-1 repeat of insulin-like growth factor (IGF)-binding proteins (IGFBPs) -3, -5, and -6 inhibit IGFBP-4 degradation. Endocrinology 138:2280-5
Fowlkes, J L; Serra, D M (1996) Characterization of glycosaminoglycan-binding domains present in insulin-like growth factor-binding protein-3. J Biol Chem 271:14676-9
Wenstrup, R J; Fowlkes, J L; Witte, D P et al. (1996) Discordant expression of osteoblast markers in MC3T3-E1 cells that synthesize a high turnover matrix. J Biol Chem 271:10271-6
Fowlkes, J L; Thrailkill, K M; Serra, D M et al. (1995) Matrix metalloproteinases as insulin-like growth factor binding protein-degrading proteinases. Prog Growth Factor Res 6:255-63
Fowlkes, J L; Serra, D M; Rosenberg, C K et al. (1995) Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) functions as an IGF-reversible inhibitor of IGFBP-4 proteolysis. J Biol Chem 270:27481-8
Thrailkill, K M; Quarles, L D; Nagase, H et al. (1995) Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation. Endocrinology 136:3527-33