Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08DK002308-01A2
Application #
2134200
Study Section
Special Emphasis Panel (SRC)
Project Start
1996-07-01
Project End
2001-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Zhu, Yanqing; Casado, Marta; Vaulont, Sophie et al. (2005) Role of upstream stimulatory factors in regulation of renal transforming growth factor-beta1. Diabetes 54:1976-84
Tsuchida, Ken-ichi; Zhu, Yanqing; Siva, Senthuran et al. (2003) Role of Smad4 on TGF-beta-induced extracellular matrix stimulation in mesangial cells. Kidney Int 63:2000-9
Sharma, K; Mc Gowan, T A; Wang, L et al. (2000) Inhibition of type I and III IP(3)Rs by TGF-beta is associated with impaired calcium release in mesangial cells. Am J Physiol Renal Physiol 278:F1022-9
McGowan, T A; Sharma, K (2000) Regulation of inositol 1,4,5-trisphosphate receptors by transforming growth factor-beta: implications for vascular dysfunction in diabetes. Kidney Int Suppl 77:S99-103
Sharma, K; Wang, L; Zhu, Y et al. (1999) Renal type I inositol 1,4,5-trisphosphate receptor is reduced in streptozotocin-induced diabetic rats and mice. Am J Physiol 276:F54-61
Sharma, K; Eltayeb, B O; McGowan, T A et al. (1999) Captopril-induced reduction of serum levels of transforming growth factor-beta1 correlates with long-term renoprotection in insulin-dependent diabetic patients. Am J Kidney Dis 34:818-23
Sharma, K; Considine, R V (1998) The Ob protein (leptin) and the kidney. Kidney Int 53:1483-7
Wang, L; Zhu, Y; Sharma, K (1998) Transforming growth factor-beta1 stimulates protein kinase A in mesangial cells. J Biol Chem 273:8522-7
Cohen, M P; Sharma, K; Guo, J et al. (1998) The renal TGF-beta system in the db/db mouse model of diabetic nephropathy. Exp Nephrol 6:226-33
Sharma, K; Wang, L; Zhu, Y et al. (1997) Transforming growth factor-beta1 inhibits type I inositol 1,4,5-trisphosphate receptor expression and enhances its phosphorylation in mesangial cells. J Biol Chem 272:14617-23

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