Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08DK002318-03
Application #
2134220
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1994-07-01
Project End
1999-06-30
Budget Start
1996-08-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Denson, L A; Sturm, E; Echevarria, W et al. (2001) The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Gastroenterology 121:140-7
Denson, L A; Menon, R K; Shaufl, A et al. (2001) TNF-alpha downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding. J Clin Invest 107:1451-8
Denson, L A; Karpen, S J; Bogue, C W et al. (2000) Divergent homeobox gene hex regulates promoter of the Na(+)-dependent bile acid cotransporter. Am J Physiol Gastrointest Liver Physiol 279:G347-55
Denson, L A; Auld, K L; Schiek, D S et al. (2000) Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation. J Biol Chem 275:8835-43
Denson, L A; McClure, M H; Bogue, C W et al. (2000) HNF3beta and GATA-4 transactivate the liver-enriched homeobox gene, Hex. Gene 246:311-20
Konieczko, E M; Ralston, A K; Crawford, A R et al. (1998) Enhanced Na+-dependent bile salt uptake by WIF-B cells, a rat hepatoma hybrid cell line, following growth in the presence of a physiological bile salt. Hepatology 27:191-9
Trauner, M; Arrese, M; Lee, H et al. (1998) Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J Clin Invest 101:2092-100
Ganguly, T C; O'Brien, M L; Karpen, S J et al. (1997) Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5. J Clin Invest 99:2906-14
Karpen, S J; Sun, A Q; Kudish, B et al. (1996) Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter. J Biol Chem 271:15211-21