PIT-1 and Thyrotropin Beta Subunit Gene Expression

Haugen, Bryan R.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Clinical Investigator Award (CIA) (K08)
• Project #: 5K08DK002331-02
• Application #: 2134242
• Study Section: Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
• Project Start: 1995-01-01
• Project End: 1999-12-31
• Budget Start: 1996-01-19
• Budget End: 1996-12-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: University of Colorado Denver
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 065391526
• City: Aurora
• State: CO
• Country: United States
• Zip Code: 80045

Publications

Brown, N S; Smart, A; Sharma, V et al. (2000) Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse. J Clin Invest 106:73-9

Haugen, B R; Brown, N S; Wood, W M et al. (1997) The thyrotrope-restricted isoform of the retinoid-X receptor-gamma1 mediates 9-cis-retinoic acid suppression of thyrotropin-beta promoter activity. Mol Endocrinol 11:481-9

Gordon, D F; Lewis, S R; Haugen, B R et al. (1997) Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoter. J Biol Chem 272:24339-47

Haugen, B R; Nawaz, S; Markham, N et al. (1997) Telomerase activity in benign and malignant thyroid tumors. Thyroid 7:337-42

Haugen, B R; McDermott, M T; Gordon, D F et al. (1996) Determinants of thyrotrope-specific thyrotropin beta promoter activation. Cooperation of Pit-1 with another factor. J Biol Chem 271:385-9

Ng, L; Forrest, D; Haugen, B R et al. (1995) N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone. Mol Endocrinol 9:1202-13