|
Costa-Santos, Marivania; Kater, Claudio E; Dias, Eduardo P et al. (2004) Two intronic mutations cause 17-hydroxylase deficiency by disrupting splice acceptor sites: direct demonstration of aberrant splicing and absent enzyme activity by expression of the entire CYP17 gene in HEK-293 cells. J Clin Endocrinol Metab 89:43-8
|
|
Costa-Santos, Marivania; Kater, Claudio E; Auchus, Richard J et al. (2004) Two prevalent CYP17 mutations and genotype-phenotype correlations in 24 Brazilian patients with 17-hydroxylase deficiency. J Clin Endocrinol Metab 89:49-60
|
|
Khan, Naveed; Sharma, Kamalesh K; Andersson, Stefan et al. (2004) Human 17beta-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells. Arch Biochem Biophys 429:50-9
|
|
Fluck, Christa E; Miller, Walter L; Auchus, Richard J (2003) The 17, 20-lyase activity of cytochrome p450c17 from human fetal testis favors the delta5 steroidogenic pathway. J Clin Endocrinol Metab 88:3762-6
|
|
Gupta, Manisha K; Guryev, Oleg L; Auchus, Richard J (2003) 5alpha-reduced C21 steroids are substrates for human cytochrome P450c17. Arch Biochem Biophys 418:151-60
|
|
Sherbet, Daniel P; Tiosano, Dov; Kwist, Kerri M et al. (2003) CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding. J Biol Chem 278:48563-9
|
|
Wilson, Jean D; Auchus, Richard J; Leihy, Michael W et al. (2003) 5alpha-androstane-3alpha,17beta-diol is formed in tammar wallaby pouch young testes by a pathway involving 5alpha-pregnane-3alpha,17alpha-diol-20-one as a key intermediate. Endocrinology 144:575-80
|
|
Mathieu, Axel P; LeHoux, Jean Guy; Auchus, Richard J (2003) Molecular dynamics of substrate complexes with hamster cytochrome P450c17 (CYP17): mechanistic approach to understanding substrate binding and activities. Biochim Biophys Acta 1619:291-300
|
|
Auchus, Richard J; Sampath Kumar, A; Andrew Boswell, C et al. (2003) The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21. Arch Biochem Biophys 409:134-44
|
|
Arlt, Wiebke; Martens, John W M; Song, Maengseok et al. (2002) Molecular evolution of adrenarche: structural and functional analysis of p450c17 from four primate species. Endocrinology 143:4665-72
|
Showing the most recent 10 out of 20 publications
