Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08DK002469-01
Application #
2015661
Study Section
Special Emphasis Panel (SRC)
Project Start
1996-09-30
Project End
2001-08-31
Budget Start
1996-09-30
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Gobert, Alain P; Cheng, Yulan; Akhtar, Mahmood et al. (2004) Protective role of arginase in a mouse model of colitis. J Immunol 173:2109-17
Meyer, Frank; Ramanujam, Kalathur S; Gobert, Alain P et al. (2003) Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori. J Immunol 171:3913-7
Wilson, K T (2002) Angiogenic markers, neovascularization and malignant deformation of Barrett's esophagus. Dis Esophagus 15:16-21
Rafiee, Parvaneh; Johnson, Christopher P; Li, Mona S et al. (2002) Cyclosporine A enhances leukocyte binding by human intestinal microvascular endothelial cells through inhibition of p38 MAPK and iNOS. Paradoxical proinflammatory effect on the microvascular endothelium. J Biol Chem 277:35605-15
Gobert, Alain P; Mersey, Benjamin D; Cheng, Yulan et al. (2002) Cutting edge: urease release by Helicobacter pylori stimulates macrophage inducible nitric oxide synthase. J Immunol 168:6002-6
Gobert, Alain P; Cheng, Yulan; Wang, Jian-Ying et al. (2002) Helicobacter pylori induces macrophage apoptosis by activation of arginase II. J Immunol 168:4692-700
Gobert, A P; McGee, D J; Akhtar, M et al. (2001) Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: a strategy for bacterial survival. Proc Natl Acad Sci U S A 98:13844-9
Akhtar, M; Cheng, Y; Magno, R M et al. (2001) Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells. Cancer Res 61:2399-403
Binion, D G; Rafiee, P; Ramanujam, K S et al. (2000) Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. Free Radic Biol Med 29:881-8
Meyer, F; Wilson, K T; James, S P (2000) Modulation of innate cytokine responses by products of Helicobacter pylori. Infect Immun 68:6265-72

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