I now propose to study the interaction of undernutrition, TH, and IGF-I in brain development. Focusing on early postnatal brain development in the mouse, the time when brain IGF-I expression, b) determine the influence of undernutrition on the expression of the type I IGF and related receptors and on IGF binding proteins, and finally, c) using transgenic mouse models of IGF-I availability, determine whether IGF-I can alter brain pathophysiology resulting from undernutrition. This research will extend my skills to a wide range of experimental approaches and to the techniques of molecular and cell biology. These experiences, together with a broadening of my basic science knowledge, should provide me with the tools to become an independent investigator and academician.
| Calikoglu, A; Karayal, A; D'Ercole, A (2001) Nutritional regulation of IGF-I expression during brain development in mice. Pediatr Res 49:197-202 |
| Chrysis, D; Calikoglu, A S; Ye, P et al. (2001) Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner. J Neurosci 21:1481-9 |
| Elder, D A; Karayal, A F; D'Ercole, A J et al. (2000) Effects of hypothyroidism on insulin-like growth factor-I expression during brain development in mice. Neurosci Lett 293:99-102 |
| Lee, K H; Calikoglu, A S; Ye, P et al. (1999) Insulin-like growth factor-I (IGF-I) ameliorates and IGF binding protein-1 (IGFBP-1) exacerbates the effects of undernutrition on brain growth during early postnatal life: studies in IGF-I and IGFBP-1 transgenic mice. Pediatr Res 45:331-6 |
