application) This is a resubmission of DK02767 """"""""High glycemic diet and risk of type 2 DM and CRD, """""""" a K08 program for advanced training and research leading to a career as an independent clinical scientist in diabetes and cardiovascular epidemiology with particular emphasis on nutrition and prevention of chronic disease. The candidate will develop, refine, and validate the Nurses' Health Study (NHS) database for both the glycemic and insulin indices to assess each NHS participant's long term dietary glycemic load and insulin demand and evaluate their potential effects on the incidence of type 2 diabetes mellitus (DM) and coronary heart disease (CHD). In this resubmission, we have substantially revised the proposal, taking into account each of the major concerns raised by the reviewers. We continue to focus on a comprehensive evaluation of the effects of carbohydrates on disease risk using prospectively collected dietary data and blood samples in the NHS. We have added two new components including a) validating the two dietary variables-glycemic index and insulinemic index-using a series of biomarkers including glycosylated hemoglobin Alc (HbAlc), C-peptide, triglyceride (TG), and insulin; and b) expanding the scope of the nested case-control studies to further understand the relations of dietary carbohydrate, glycemic index and load, and insulin index and load with risk of type 2 LIM and CHD. Further, we provide new preliminary data relating dietary glycemic index and carbohydrate intake assessed by our food frequency questionnaire to fasting TG in a sample of nurses without DM and CHD who provided fasting blood samples. In addition, we provide a critical review of the available literature regarding the clinical usefulness of glycemic index. We believe that the detailed exposure information and multiple dietary assessments in this large prospective cohort of 121, 700 women offer a unique opportunity to study the controversial topic of the health effects of carbohydrate quality. Through the process, Dr. Liu will acquire ample skills and experience to become an independent clinician scientist and educator in the field of nutrition and chronic disease prevention and control.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08DK002767-03
Application #
6524210
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
2000-08-15
Project End
2003-07-31
Budget Start
2002-08-01
Budget End
2003-07-31
Support Year
3
Fiscal Year
2002
Total Cost
$130,815
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Livesey, Geoffrey; Taylor, Richard; Livesey, Helen et al. (2013) Is there a dose-response relation of dietary glycemic load to risk of type 2 diabetes? Meta-analysis of prospective cohort studies. Am J Clin Nutr 97:584-96
Ye, Eva Qing; Chacko, Sara A; Chou, Elizabeth L et al. (2012) Greater whole-grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gain. J Nutr 142:1304-13
Li, Chaoyang; Ford, Earl S; Zhao, Guixiang et al. (2011) Serum ?-carotene concentrations and risk of death among US Adults: the Third National Health and Nutrition Examination Survey Follow-up Study. Arch Intern Med 171:507-15
Roberts, Christian K; Liu, Simin (2009) Carbohydrate intake and obesity: an association that needs ""refining"". J Am Diet Assoc 109:1163-4
Song, Yiqing; Manson, JoAnn E; Buring, Julie E et al. (2004) A prospective study of red meat consumption and type 2 diabetes in middle-aged and elderly women: the women's health study. Diabetes Care 27:2108-15
Higginbotham, Susan; Zhang, Zuo-Feng; Lee, I-Min et al. (2004) Dietary glycemic load and breast cancer risk in the Women's Health Study. Cancer Epidemiol Biomarkers Prev 13:65-70
Liu, Simin; Song, Yiqing; Hu, Frank B et al. (2004) A prospective study of the APOA1 XmnI and APOC3 SstI polymorphisms in the APOA1/C3/A4 gene cluster and risk of incident myocardial infarction in men. Atherosclerosis 177:119-26
Higginbotham, Susan; Zhang, Zuo-Feng; Lee, I-Min et al. (2004) Dietary glycemic load and risk of colorectal cancer in the Women's Health Study. J Natl Cancer Inst 96:229-33
Janket, Sok-Ja; Manson, JoAnn E; Sesso, Howard et al. (2003) A prospective study of sugar intake and risk of type 2 diabetes in women. Diabetes Care 26:1008-15
Liu, Simin; Ma, Jing; Ridker, Paul M et al. (2003) A prospective study of the association between APOE genotype and the risk of myocardial infarction among apparently healthy men. Atherosclerosis 166:323-9

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