Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08DK062805-02
Application #
6696967
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
2003-01-15
Project End
2007-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$125,010
Indirect Cost
Name
University of Iowa
Department
Surgery
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Samuel, Isaac; Tephly, Linda; Williard, Deborah E et al. (2008) Enteral exclusion increases MAP kinase activation and cytokine production in a model of gallstone pancreatitis. Pancreatology 8:6-14
Meyerholz, David K; Williard, Deborah E; Grittmann, Ana-Maria et al. (2008) Murine pancreatic duct ligation induces stress kinase activation, acute pancreatitis, and acute lung injury. Am J Surg 196:675-82
Samuel, Isaac (2008) Bile and pancreatic juice exclusion activates acinar stress kinases and exacerbates gallstone pancreatitis. Surgery 143:434-40
Meyerholz, David K; Samuel, Isaac (2007) Morphologic characterization of early ligation-induced acute pancreatitis in rats. Am J Surg 194:652-8
Samuel, Isaac; Yorek, Mark A; Zaheer, Asgar et al. (2006) Bile-pancreatic juice exclusion promotes Akt/NF-kappaB activation and chemokine production in ligation-induced acute pancreatitis. J Gastrointest Surg 10:950-9
Mattson, David L; Kunert, Mary Pat; Roman, Richard J et al. (2005) Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat. Am J Physiol Renal Physiol 288:F1015-22
Samuel, Isaac; Zaheer, Smita; Zaheer, Asgar (2005) Bile-pancreatic juice exclusion increases p38MAPK activation and TNF-alpha production in ligation-induced acute pancreatitis in rats. Pancreatology 5:20-6
Samuel, Isaac; Chaudhary, Ashok; Fisher, Rory A et al. (2005) Exacerbation of acute pancreatitis by combined cholinergic stimulation and duct obstruction. Am J Surg 190:721-4
Samuel, Isaac; Toriumi, Yasuo; Zaheer, Asgar et al. (2004) Mechanism of acute pancreatitis exacerbation by enteral bile-pancreatic juice exclusion. Pancreatology 4:527-32
Samuel, Isaac; Zaheer, Asgar; Zaheer, Smita et al. (2004) Bile-pancreatic juice exclusion increases cholinergic M3 and CCK-A receptor expression and interleukin-6 production in ligation-induced acute pancreatitis. Am J Surg 188:511-5

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