This K08 proposal will complete Hallie Prescott, MD; MSc's training towards her long-term career goal of improving the long-term survival and quality of life of critical illness survivors. Dr. Prescott is a pulmonary & critical care physician and scientist at the University of Michigan, with Master's training in clinical study design and biostatistics. This proposal builds on Dr. Prescott's prior experience, leveraging advanced statistical methods, granular clinical data, and the rich training environment at University of Michigan to improve our understanding and management of post-sepsis morbidity. The research will be completed under the guidance of primary mentor Theodore J. Iwashyna, MD, PhD, co-mentor Kenneth Langa, MD, PhD, and co-mentor Richard Gonzalez, PhD, with a planned mentor-the-mentor strategy and additional input from an advisory board of physician-scientists. This 5-year plan includes formal coursework, professional development, and mentored research, with defined milestones to ensure productivity and a successful transition to independence. This mentored research has 2 specific Scientific Aims:
AIM 1 : Test the relative importance 3 competing hypotheses for the general pathway of post- sepsis morbidity. * AIM 2: Develop a diagnosis-specific readmission risk profile tool to personalize treatment for severe sepsis survivors in the immediate (90-day) post-hospital setting. Inherent to completing these high-level Aims, Dr. Prescott will also (1) characterize the epidemiology of multi- morbidity and hospitalization in severe sepsis survivors, (2) identify the health conditions most increased after severe sepsis, (3) define the incremental benefits of specific clinical data in improving risk prediction, (4) compare the accuracy and usability of complementary cutting edge personalized prediction methodologies. This work will build to at least two R01 proposals: (1) to examine the mechanism by which a specific chronic health condition is increased after severe sepsis (as identified in Aim 1) or to examine how post-sepsis morbidity differs from that of less-severe infections and sterile inflammation, and (2) to implement and evaluate the diagnosis-specific risk profile tool developed in Aim 2. Beyond establishing the foundation for a programmatic line of research to improve the care of severe sepsis survivors, this proposal will provide Dr. Prescott with research skills that are readily applicable to additional domains of critical illness research In short, this K08 award will support and accelerate the career development activities of Dr. Prescott and allow her to successfully launch into the next phase of her career as an independent investigator.

Public Health Relevance

Hundreds of thousands of Americans survive severe sepsis each year and face increased rates of hospitalization, co-morbid illness, and early death. Yet, we lack a unified understanding of how severe sepsis confers long-term morbidity, and have limited ability to identify those patients at greatest risk of specific adverse outcomes. Correctin these deficits, as proposed in this project, is of great public health importance to the large and growing population of severe sepsis survivors, as it offers the prospect of a more rapid recovery process, reduced health care needs, and better quality of life.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08GM115859-04
Application #
9534693
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Dunsmore, Sarah
Project Start
2015-08-15
Project End
2019-07-31
Budget Start
2018-08-01
Budget End
2019-07-31
Support Year
4
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Levy, Mitchell M; Gesten, Foster C; Phillips, Gary S et al. (2018) Mortality Changes Associated with Mandated Public Reporting for Sepsis. The Results of the New York State Initiative. Am J Respir Crit Care Med 198:1406-1412
Prescott, Hallie C; Cope, Tara M; Gesten, Foster C et al. (2018) Reporting of Sepsis Cases for Performance Measurement Versus for Reimbursement in New York State. Crit Care Med 46:666-673
Prescott, Hallie C; Angus, Derek C (2018) Enhancing Recovery From Sepsis: A Review. JAMA 319:62-75
Meyer, Nathaniel; Harhay, Michael O; Small, Dylan S et al. (2018) Temporal Trends in Incidence, Sepsis-Related Mortality, and Hospital-Based Acute Care After Sepsis. Crit Care Med 46:354-360
Prescott, Hallie C; Costa, Deena Kelly (2018) Improving Long-Term Outcomes After Sepsis. Crit Care Clin 34:175-188
Prescott, Hallie C (2018) Preventing Chronic Critical Illness and Rehospitalization: A Focus on Sepsis. Crit Care Clin 34:501-513
Royer, Stephanie; Prescott, Hallie C (2018) Next Steps for Confirming Bronchoalveolar Lavage Amlyase as an Useful Biomarker for Ventilator-Associated Pneumonia. Crit Care Med 46:165-166
Prescott, Hallie C; Angus, Derek C (2018) Postsepsis Morbidity. JAMA 319:91
Haak, Bastiaan W; Prescott, Hallie C; Wiersinga, W Joost (2018) Therapeutic Potential of the Gut Microbiota in the Prevention and Treatment of Sepsis. Front Immunol 9:2042
Prescott, Hallie C; Carmichael, Alicia; Langa, Kenneth M et al. (2018) Paths into Sepsis: Trajectories of Pre-Sepsis Healthcare Use. Ann Am Thorac Soc :

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