description): The objectives of this application are to determine the mechanisms involved in X chromosome inactivation and to understand the impact of this process on human X-linked disorders. The mechanisms involved in determining which genes are expressed from the inactive X and which ones are silenced are currently unknown.
The specific aims of this application are: (1) to determine whether there is a """"""""domain"""""""" of genes on the mouse X chromosome that escapes inactivation; (2) to define the characteristics of the mouse X chromosome with respect to inactivation status; and (3) to determine whether the inactivation status of a gene is determined at the level of chromosomal domains or on an individual gene basis.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Clinical Investigator Award (CIA) (K08)
Project #
7K08HD001177-04
Application #
6221359
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Hanson, James W
Project Start
1997-04-01
Project End
2002-03-31
Budget Start
2000-02-01
Budget End
2000-03-31
Support Year
4
Fiscal Year
2000
Total Cost
$15,014
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pathology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212