description): The proposal consists of six Specific Aims and the experiments that will achieve these aims.
The aims are: 1. To determine the location(s) of G-CSF-R in the human placenta, at various stages of development, 2. To determine the function(s) of G-CSF in the human placenta, 3. To determine the location(s) of G-CSF production in the human placenta, at various stages development, 4. To determine the effect(s) of human intra-amniotic infection on placental production of G-CSF-R and G-CSF, 5. To quantify transplacental passage of G-CSF during term and preterm pregnancy in rats, and 6. To quantify transplacental passage of G-CSF during term and preterm normal and infected human gestations. The results will help clarify the location and function of placental G-CSF and G-CSF-R during human development, in health and during intra-amniotic infection, and the basic mechanistic events central to the pathogenesis of preterm labor and early-onset neonatal bacterial infection.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Clinical Investigator Award (CIA) (K08)
Project #
Application #
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Ilekis, John V
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University of South Florida
Schools of Medicine
United States
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Gersting, Jason A; Kotto-Kome, Catherine A; Du, Yan et al. (2003) Bioavailability of granulocyte colony-stimulating factor administered enterally to suckling mice. Pharmacol Res 48:643-7

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