description): Hox proteins have been implicated in the organization of body morphology and have specific temporal and spatial patterns of expression. It has been suggested that Hox proteins specific the position and polarity of the tetrapod limbs, yet the mechanisms by which this may be achieved are largely unknown. Retinoids can regulate limb patterning and Hox gene expression. Recent studies suggest that Hox genes of groups 5 to 8 may specify, forelimb position and be regulated by retinoids. The applicant proposes a four year career development program to systematic test this hypothesis using chick and mouse embryos.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HD001204-04
Application #
2888728
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Javois, Lorette Claire
Project Start
1997-09-30
Project End
2001-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Loma Linda University
Department
Anatomy/Cell Biology
Type
Schools of Dentistry
DUNS #
City
Loma Linda
State
CA
Country
United States
Zip Code
92350
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Dreyer, S D; Morello, R; German, M S et al. (2000) LMX1B transactivation and expression in nail-patella syndrome. Hum Mol Genet 9:1067-74
Bejjani, B A; Oberg, K C; Wilkins, I et al. (1998) Prenatal ultrasonographic description and postnatal pathological findings in atelosteogenesis type 1. Am J Med Genet 79:392-5