Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL001027-05
Application #
3081646
Study Section
(SRC)
Project Start
1982-07-01
Project End
1987-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Parsons, W J; Ramkumar, V; Stiles, G L (1988) The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi. Mol Pharmacol 33:441-8
Ramkumar, V; Stiles, G L (1988) The new positive inotrope sulmazole inhibits the function of guanine nucleotide regulatory proteins by affecting GTP turnover. Mol Pharmacol 34:761-8
Parsons, W J; Ramkumar, V; Stiles, G L (1988) Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi. Mol Pharmacol 34:37-41
Stiles, G L; Jacobson, K A (1987) A new high affinity, iodinated adenosine receptor antagonist as a radioligand/photoaffinity crosslinking probe. Mol Pharmacol 32:184-8
Parsons, W J; Stiles, G L (1987) Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes. Regulation of both Ns and Ni. J Biol Chem 262:841-7
Green, R M; Stiles, G L (1986) Chronic caffeine ingestion sensitizes the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex. J Clin Invest 77:222-7
Stiles, G L; Daly, D T; Olsson, R A (1986) Characterization of the A1 adenosine receptor-adenylate cyclase system of cerebral cortex using an agonist photoaffinity ligand. J Neurochem 47:1020-5
Stiles, G L; Pierson, G; Sunay, S et al. (1986) The rat testicular A1 adenosine receptor-adenylate cyclase system. Endocrinology 119:1845-51
Stiles, G L (1986) Photoaffinity cross-linked A1 adenosine receptor-binding subunits. Homologous glycoprotein expression by different tissues. J Biol Chem 261:10839-43
Stiles, G L; Daly, D T; Olsson, R A (1985) The A1 adenosine receptor. Identification of the binding subunit by photoaffinity cross-linking. J Biol Chem 260:10806-11

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