The long term objectives are to understand the physiologic changes that occur during the growth and development of the respiratory system as well as the changes produced by injury to the lungs early in life. In infancy, the two primary insults to the lungs occur from lower respiratory tract infections (LRI) and the medical support required or premature infants which results in bronchopulmonary dysplasia (BDP). There has been increasing concern that these early pulmonary insults may have chronic sequellae and contribute to the development of chronic obstructive airways disease in adults. Pulmonary function testing in infants has been limited by patient cooperation and the lack of easily performed, non-invasive procedures. Non-invasive techniques for obtaining partial expiratory flow-volume curves and total respiratory system compliance have recently been described for use in infants. This investigator proposes to employ these techniques in the following studies: 1) classify BPD in terms of the degree of pulmonary dysfunction. 2) evaluate bronchodilator responsiveness in infants with BPD and with LRI. 3) evaluate prospectively the relationships of LRI's pulmonary function and bronchial reactivity during the first year of life. 4) evaluate the relationship between the progression of pulmonary dysfunction and bronchidilator responsiveness as infants progress from respiratory distress syndrome to BPD.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Clinical Investigator Award (CIA) (K08)
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Indiana University-Purdue University at Indianapolis
Schools of Medicine
United States
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Tepper, R S; Rosenberg, D; Eigen, H et al. (1994) Bronchodilator responsiveness in infants with bronchiolitis. Pediatr Pulmonol 17:81-5
Tepper, R S; Montgomery, G L; Ackerman, V et al. (1993) Longitudinal evaluation of pulmonary function in infants and very young children with cystic fibrosis. Pediatr Pulmonol 16:96-100
Tepper, R S; Reister, T (1993) Forced expiratory flows and lung volumes in normal infants. Pediatr Pulmonol 15:357-61
Yoder Jr, M C; Chua, R; Tepper, R (1991) Effect of dexamethasone on pulmonary inflammation and pulmonary function of ventilator-dependent infants with bronchopulmonary dysplasia. Am Rev Respir Dis 143:1044-8
Ackerman, V; Montogomery, G; Eigen, H et al. (1991) Assessment of airway responsiveness in infants with cystic fibrosis. Am Rev Respir Dis 144:344-6
Howenstine, M; Eigen, H; Tepper, R (1991) Pulmonary function in infants after pertussis. J Pediatr 118:563-6
Montgomery, G L; Tepper, R S (1990) Changes in airway reactivity with age in normal infants and young children. Am Rev Respir Dis 142:1372-6
Tepper, R S; Eigen, H; Brown, J et al. (1989) Use of maximal expiratory flows to evaluate central airways obstruction in infants. Pediatr Pulmonol 6:272-4
Morgan, W J; Geller, D E; Tepper, R S et al. (1988) Partial expiratory flow-volume curves in infants and young children. Pediatr Pulmonol 5:232-43
Hiatt, P; Eigen, H; Yu, P et al. (1988) Bronchodilator responsiveness in infants and young children with cystic fibrosis. Am Rev Respir Dis 137:119-22

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