Abstract

During the next five years of my studies will be directed towards understanding the distribution of coronary microvascular resistance in animals with hypertension and left ventricular hypertrophy (HT- LVH). These studies evaluate the effects of hypertension and left ventricular hypertrophy on: the distribution of coronary microvascular resistance, the microvascular site for autoregulation, the effects of adenosine vasodilatation, characteristics of microvascular permeability, quantitation of microvascular permeability and the microvascular responses to acute myocardial ischemia. To evaluate these mechanisms we have developed a system whereby left ventricular microvascular pressures, diameters and a direct evaluation of permeability are performed in epicardial microvessels of the freely beating left ventricle in both normal animals and animals with hypertension and left ventricular hypertrophy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08HL002198-01A1
Application #
3082587
Study Section
(SRC)
Project Start
1989-04-01
Project End
1994-03-31
Budget Start
1989-04-01
Budget End
1990-03-31
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Kersten, J R; Brooks, L A; Dellsperger, K C (1995) Impaired microvascular response to graded coronary occlusion in diabetic and hyperglycemic dogs. Am J Physiol 268:H1667-74
Bellary, S S; Anderson, K W; Arden, W A et al. (1995) Effect of lipopolysaccharide on the physical conformation of the erythrocyte cytoskeletal proteins. Life Sci 56:91-8
Bellary, S; Arden, W W; Schwartz, R W et al. (1995) Effect of lipopolysaccharide, leukocytes, and monoclonal anti-lipid A antibodies on erythrocyte membrane elastance. Shock 3:132-6
Eller, B T; Brooks, L A; Dellsperger, K C (1995) Thromboxane contributes to submaximal coronary dilation during myocardial ischemia. Microcirculation 2:165-72
Komaru, T; Lamping, K G; Dellsperger, K C (1994) Role of adenosine in vasodilation of epimyocardial coronary microvessels during reduction in perfusion pressure. J Cardiovasc Pharmacol 24:434-42
Schork, N J; Weder, A B; Trevisan, M et al. (1994) The contribution of pleiotropy to blood pressure and body-mass index variation: the Gubbio Study. Am J Hum Genet 54:361-73
Dellsperger, K C (1993) Transthoracic echocardiography for evaluation of hypertensive heart disease. Echocardiography 10:295-302
Fujii, M; Nuno, D W; Lamping, K G et al. (1992) Effect of hypertension and hypertrophy on coronary microvascular pressure. Circ Res 71:120-6
Komaru, T; Lamping, K G; Eastham, C L et al. (1991) Effect of an arginine analogue on acetylcholine-induced coronary microvascular dilatation in dogs. Am J Physiol 261:H2001-7
Komaru, T; Lamping, K G; Eastham, C L et al. (1991) Role of ATP-sensitive potassium channels in coronary microvascular autoregulatory responses. Circ Res 69:1146-51

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