Abstract

This proposal seeks to understand the molecular basis for adherence between human neurophils and endothelial cells. The specific goal of this proposal is to identify regionss of the CD11b subunit of the neutrophil adherence receptor (CD11b/CD18) wnich are critical for adhesion to endothelial cells.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08HL002637-01
Application #
3083068
Study Section
Research Manpower Review Committee (MR)
Project Start
1991-09-30
Project End
1994-09-29
Budget Start
1991-09-30
Budget End
1992-09-29
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Hickstein, D D; Grunvald, E; Shumaker, G et al. (1993) Transfected leukocyte integrin CD11b/CD18 (Mac-1) mediates phorbol ester-activated, homotypic cell:cell adherence in the K562 cell line. Blood 82:2537-45
Hickstein, D D; Baker, D M; Gollahon, K A et al. (1992) Identification of the promoter of the myelomonocytic leukocyte integrin CD11b. Proc Natl Acad Sci U S A 89:2105-9