Dr. Lawrence J. Appel is a promising young faculty member who has made a substantial commitment to a career in clinical investigation. This commitment is evidenced by pursuit of advanced clinical and research training including a Chief Residency in Internal Medicine, a Masters Degree in Public Health, and a three year clinical research fellowship. More importantly, his training provides a solid foundation for him to address clinical research problems in a methodologically rigorous fashion. To this end, the proposed study builds upon his previous research efforts and addresses a question of fundamental importance to the hypertension research, health care provider, and health policy communities. Cardiovascular risk prediction remains imprecise due in part to suboptimal measurement of risk factors such as blood pressure (BP). Ambulatory BP monitoring (ABPM) represents a potentially important advance in the measurement of BP, but its role in cardiovascular risk prediction remains unproven. To answer this question, the CIA applicant will initiate a concurrent, prospective study designed to assess the impact of ABPM on cardiovascular risk prediction in a population at enormous risk for cardiovascular disease, renal transplant recipients. The environment and resources available to the CIA candidate are impressive. Dr. Paul K. Whelton, an accomplished investigator with expertise in the fields of hypertension, renal disease epidemiology and cardiovascular epidemiology, is the candidate's research mentor and will serve as his sponsor. In this role, Dr. Whelton will ensure that the candidate benefits from the tremendous resources of the Johns Hopkins Medical Institutions, particularly those of the Outpatient General Clinical Research Center and the Welch Center for Prevention, Epidemiology and Clinical Research. Receipt of a CIA will complement these resources by providing the candidate with the protected time necessary for him to reach his full potential as a clinical investigator.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08HL002642-01A1
Application #
3083076
Study Section
Special Emphasis Panel (SRC (FB))
Project Start
1992-07-01
Project End
1997-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Vollmer, W M; Appel, L J; Svetkey, L P et al. (2005) Comparing office-based and ambulatory blood pressure monitoring in clinical trials. J Hum Hypertens 19:77-82
Erlinger, Thomas P; Vollmer, William M; Svetkey, Laura P et al. (2003) The potential impact of nonpharmacologic population-wide blood pressure reduction on coronary heart disease events: pronounced benefits in African-Americans and hypertensives. Prev Med 37:327-33
Kostis, John B; Wilson, Alan C; Shindler, Daniel M et al. (2002) Persistence of normotension after discontinuation of lifestyle intervention in the trial of TONE. Trial of Nonpharmacologic Interventions in the Elderly. Am J Hypertens 15:732-4
Young, D R; Jee, S H; Appel, L J (2001) A comparison of the Yale Physical Activity Survey with other physical activity measures. Med Sci Sports Exerc 33:955-61
Appel, L J; Espeland, M A; Easter, L et al. (2001) Effects of reduced sodium intake on hypertension control in older individuals: results from the Trial of Nonpharmacologic Interventions in the Elderly (TONE). Arch Intern Med 161:685-93
Moore, T J; Conlin, P R; Ard, J et al. (2001) DASH (Dietary Approaches to Stop Hypertension) diet is effective treatment for stage 1 isolated systolic hypertension. Hypertension 38:155-8
Huang, H Y; Maguire, M G; Miller 3rd, E R et al. (2000) Impact of pill organizers and blister packs on adherence to pill taking in two vitamin supplementation trials. Am J Epidemiol 152:780-7
Appel, L J; Miller 3rd, E R; Jee, S H et al. (2000) Effect of dietary patterns on serum homocysteine: results of a randomized, controlled feeding study. Circulation 102:852-7
Young, D R; Appel, L J; Jee, S et al. (1999) The effects of aerobic exercise and T'ai Chi on blood pressure in older people: results of a randomized trial. J Am Geriatr Soc 47:277-84
Miller 3rd, E R; Appel, L J (1998) The abrupt onset of Graves' disease: documentation in the setting of a controlled feeding study. Am J Med 104:487-8

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