Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL002728-05
Application #
2210456
Study Section
Special Emphasis Panel (SRC (FB))
Project Start
1992-04-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Farrehi, P M; Zhu, Y; Fay, W P (2001) An analysis of mechanisms underlying the antifibrinolytic properties of radiographic contrast agents. J Thromb Thrombolysis 12:273-81
Fay, W P; Parker, A C (1998) Effects of radiographic contrast agents on thrombin formation and activity. Thromb Haemost 80:266-72
Fay, W P; Bokka, L V (1998) Functional analysis of the amino- and carboxyl-termini of streptokinase. Thromb Haemost 79:985-91
Farrehi, P M; Ozaki, C K; Carmeliet, P et al. (1998) Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice. Circulation 97:1002-8
Fay, W P; Parker, A C; Condrey, L R et al. (1997) Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene. Blood 90:204-8
Eitzman, D T; McCoy, R D; Zheng, X et al. (1996) Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 97:232-7
Fay, W P; Murphy, J G; Owen, W G (1996) High concentrations of active plasminogen activator inhibitor-1 in porcine coronary artery thrombi. Arterioscler Thromb Vasc Biol 16:1277-84
Eitzman, D T; Fay, W P; Lawrence, D A et al. (1995) Peptide-mediated inactivation of recombinant and platelet plasminogen activator inhibitor-1 in vitro. J Clin Invest 95:2416-20
Fay, W P; Eitzman, D T; Shapiro, A D et al. (1994) Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms. Blood 83:351-6
Eitzman, D T; Chi, L; Saggin, L et al. (1994) Heparin neutralization by platelet-rich thrombi. Role of platelet factor 4. Circulation 89:1523-9