Red Cell Adherence to Endothelium in Sickle Cell Disease

Hillery, Cheryl A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Clinical Investigator Award (CIA) (K08)
• Project #: 5K08HL002858-03
• Application #: 2210686
• Study Section: Research Training Review Committee (RTR)
• Project Start: 1994-01-01
• Project End: 1998-12-31
• Budget Start: 1996-01-01
• Budget End: 1996-12-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: Medical College of Wisconsin
• Department: Pediatrics
• Type: Schools of Medicine
• DUNS #: 073134603
• City: Milwaukee
• State: WI
• Country: United States
• Zip Code: 53226

Publications

Hillery, C A; Du, M C; Wang, W C et al. (2000) Hydroxyurea therapy decreases the in vitro adhesion of sickle erythrocytes to thrombospondin and laminin. Br J Haematol 109:322-7

Hillery, C A; Scott, J P; Du, M C (1999) The carboxy-terminal cell-binding domain of thrombospondin is essential for sickle red blood cell adhesion. Blood 94:302-9

Hillery, C A (1998) Potential therapeutic approaches for the treatment of vaso-occlusion in sickle cell disease. Curr Opin Hematol 5:151-5

Hillery, C A; Mancuso, D J; Evan Sadler, J et al. (1998) Type 2M von Willebrand disease: F606I and I662F mutations in the glycoprotein Ib binding domain selectively impair ristocetin- but not botrocetin-mediated binding of von Willebrand factor to platelets. Blood 91:1572-81

French 2nd, J A; Kenny, D; Scott, J P et al. (1997) Mechanisms of stroke in sickle cell disease: sickle erythrocytes decrease cerebral blood flow in rats after nitric oxide synthase inhibition. Blood 89:4591-9

Hillery, C A; Du, M C; Montgomery, R R et al. (1996) Increased adhesion of erythrocytes to components of the extracellular matrix: isolation and characterization of a red blood cell lipid that binds thrombospondin and laminin. Blood 87:4879-86