Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL002917-04
Application #
2210771
Study Section
Research Training Review Committee (RTR)
Project Start
1993-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Schmidt, Amy E; Ogawa, Taketoshi; Gailani, David et al. (2004) Structural role of Gly(193) in serine proteases: investigations of a G555E (GLY193 in chymotrypsin) mutant of blood coagulation factor XI. J Biol Chem 279:29485-92
Renne, Thomas; Gailani, David; Meijers, Joost C M et al. (2002) Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein. J Biol Chem 277:4892-9
Sinha, Dipali; Marcinkiewicz, Mariola; Gailani, David et al. (2002) Molecular cloning and biochemical characterization of rabbit factor XI. Biochem J 367:49-56
Gailani, D; Ho, D; Sun, M F et al. (2001) Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential. Blood 97:3117-22
Sun, M F; Baglia, F A; Ho, D et al. (2001) Defective binding of factor XI-N248 to activated human platelets. Blood 98:125-9
Gailani, D (2001) Gene targeting in hemostasis. factor XI. Front Biosci 6:D201-7
Martincic, D; Kravtsov, V; Gailani, D (1999) Factor XI messenger RNA in human platelets. Blood 94:3397-404
Sun, M F; Zhao, M; Gailani, D (1999) Identification of amino acids in the factor XI apple 3 domain required for activation of factor IX. J Biol Chem 274:36373-8
Martincic, D; Zimmerman, S A; Ware, R E et al. (1998) Identification of mutations and polymorphisms in the factor XI genes of an African American family by dideoxyfingerprinting. Blood 92:3309-17
Zhao, M; Abdel-Razek, T; Sun, M F et al. (1998) Characterization of a heparin binding site on the heavy chain of factor XI. J Biol Chem 273:31153-9

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