Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL003310-02
Application #
2211519
Study Section
Special Emphasis Panel (ZHL1-CSR-Y (F1))
Project Start
1995-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Ilaria Jr, Robert L (2004) Animal models of chronic myelogenous leukemia. Hematol Oncol Clin North Am 18:525-43, vii
Ye, Dan; Maitra, Anirban; Timmons, Charles F et al. (2003) The epidermal growth factor receptor HER2 is not a major therapeutic target in Ewing sarcoma. J Pediatr Hematol Oncol 25:459-66
Eliazer, Susan; Spencer, Jeffrey; Ye, Dan et al. (2003) Alteration of mesodermal cell differentiation by EWS/FLI-1, the oncogene implicated in Ewing's sarcoma. Mol Cell Biol 23:482-92
Roumiantsev, S; de Aos, I E; Varticovski, L et al. (2001) The src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase. Blood 97:4-13
Silvany, R E; Eliazer, S; Wolff, N C et al. (2000) Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation. Oncogene 19:4523-30
Spencer, J A; Eliazer, S; Ilaria Jr, R L et al. (2000) Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein. J Cell Biol 150:771-84
Li, S; Ilaria Jr, R L; Million, R P et al. (1999) The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med 189:1399-412
Ilaria Jr, R L; Hawley, R G; Van Etten, R A (1999) Dominant negative mutants implicate STAT5 in myeloid cell proliferation and neutrophil differentiation. Blood 93:4154-66
Ilaria Jr, R L; Van Etten, R A (1996) P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J Biol Chem 271:31704-10