This project is intended to clarify the mechanisms of exercise intolerance in patients with heart failure, chronic obstructive lung disease and in healthy sedentary elderly persons. The specific objective is to determine whether the exercise intolerance is due to inactivity, or if these chronic diseases cause an impairment in muscle oxygen utilization.
The specific aims are threefold: 1) To determine if exercise training rehabilitates skeletal muscle function in patients with heart failure and lung disease, independent of muscle blood flow and arterial oxygenation, to equal the muscle function of age-matched normals, 2) to determine if induced heart failure in pigs impairs skeletal muscle function beyond that produced by physical inactivity, and 3) to determine if systemic factors, such as tumor necrosis factor, released in some chronic diseases cause muscle dysfunction, and reduce the muscle's ability to use oxygen. This project will extend the knowledge of exercise intolerance in patients with chronic diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL003326-05
Application #
2771152
Study Section
Research Training Review Committee (RTR)
Project Start
1994-09-20
Project End
1999-08-31
Budget Start
1998-09-01
Budget End
1999-08-31
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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