Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08HL003345-01A1
Application #
2211573
Study Section
Special Emphasis Panel (ZHL1-CSR-Y (F1))
Project Start
1996-05-01
Project End
2001-03-30
Budget Start
1996-05-01
Budget End
1997-03-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Mellon, Matthew B; Frank, Brendon T; Fang, Kenneth C (2002) Mast cell alpha-chymase reduces IgE recognition of birch pollen profilin by cleaving antibody-binding epitopes. J Immunol 168:290-7
Frank, B T; Rossall, J C; Caughey, G H et al. (2001) Mast cell tissue inhibitor of metalloproteinase-1 is cleaved and inactivated extracellularly by alpha-chymase. J Immunol 166:2783-92
Fang, K C (2000) Mesenchymal regulation of alveolar repair in pulmonary fibrosis. Am J Respir Cell Mol Biol 23:142-5
Fang, K C; Wolters, P J; Steinhoff, M et al. (1999) Mast cell expression of gelatinases A and B is regulated by kit ligand and TGF-beta. J Immunol 162:5528-35
Caughey, G H; Raymond, W W; Fang, K C (1998) Porcine origin of human sputum trypsin? Am J Physiol 275:L200-2
Caughey, G H; Blount, J L; Koerber, K L et al. (1997) Cloning and expression of the dog mast cell alpha-chymase gene. J Immunol 159:4367-75
Sommerhoff, C P; Fang, K C; Nadel, J A et al. (1996) Classical second messengers are not involved in proteinase-induced degranulation of airway gland cells. Am J Physiol 271:L796-803