Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL003374-02
Application #
2211617
Study Section
Research Training Review Committee (RTR)
Project Start
1995-09-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tulane University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Ortiz, Luis A; Champion, Hunter C; Lasky, Joseph A et al. (2002) Enalapril protects mice from pulmonary hypertension by inhibiting TNF-mediated activation of NF-kappaB and AP-1. Am J Physiol Lung Cell Mol Physiol 282:L1209-21
Ortiz, L A; Lasky, J; Gozal, E et al. (2001) Tumor necrosis factor receptor deficiency alters matrix metalloproteinase 13/tissue inhibitor of metalloproteinase 1 expression in murine silicosis. Am J Respir Crit Care Med 163:244-52
Lasky, J A; Brody, A R (2000) Interstitial fibrosis and growth factors. Environ Health Perspect 108 Suppl 4:751-62
Ortiz, L A; Lasky, J A; Safah, H et al. (1999) Exacerbation of bleomycin-induced lung injury in mice by amifostine. Am J Physiol 277:L1239-44
Ortiz, L A; Lasky, J; Lungarella, G et al. (1999) Upregulation of the p75 but not the p55 TNF-alpha receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice. Am J Respir Cell Mol Biol 20:825-33
Hagood, J S; Miller, P J; Lasky, J A et al. (1999) Differential expression of platelet-derived growth factor-alpha receptor by Thy-1(-) and Thy-1(+) lung fibroblasts. Am J Physiol 277:L218-24
Lasky, J A; Tonthat, B; Liu, J Y et al. (1998) Upregulation of the PDGF-alpha receptor precedes asbestos-induced lung fibrosis in rats. Am J Respir Crit Care Med 157:1652-7
Lasky, J A; Ortiz, L A; Tonthat, B et al. (1998) Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis. Am J Physiol 275:L365-71
Liu, J Y; Morris, G F; Lei, W H et al. (1997) Rapid activation of PDGF-A and -B expression at sites of lung injury in asbestos-exposed rats. Am J Respir Cell Mol Biol 17:129-40
Lasky, J A; Bonner, J C; Tonthat, B et al. (1996) Chrysotile asbestos induces PDGF-A chain-dependent proliferation in human and rat lung fibroblasts in vitro. Chest 109:26S-28S

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