Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08HL003569-01
Application #
2211815
Study Section
Special Emphasis Panel (ZHL1-CSR-Y (M1))
Project Start
1996-08-10
Project End
2001-07-31
Budget Start
1996-08-10
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tulane University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Ortiz, Luis A; Champion, Hunter C; Lasky, Joseph A et al. (2002) Enalapril protects mice from pulmonary hypertension by inhibiting TNF-mediated activation of NF-kappaB and AP-1. Am J Physiol Lung Cell Mol Physiol 282:L1209-21
Ortiz, L A; Lasky, J; Gozal, E et al. (2001) Tumor necrosis factor receptor deficiency alters matrix metalloproteinase 13/tissue inhibitor of metalloproteinase 1 expression in murine silicosis. Am J Respir Crit Care Med 163:244-52
Ortiz, L A; Friedman, M; Banks, W A (2001) Role of LPS and receptor subtypes in the uptake of TNF by the murine lung. Life Sci 69:791-802
Lasky, J A; Ortiz, L A (2001) Antifibrotic therapy for the treatment of pulmonary fibrosis. Am J Med Sci 322:213-21
Ortiz, L A; Lasky, J A; Safah, H et al. (1999) Exacerbation of bleomycin-induced lung injury in mice by amifostine. Am J Physiol 277:L1239-44
Ortiz, L A; Lasky, J; Lungarella, G et al. (1999) Upregulation of the p75 but not the p55 TNF-alpha receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice. Am J Respir Cell Mol Biol 20:825-33
Lasky, J A; Ortiz, L A; Tonthat, B et al. (1998) Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis. Am J Physiol 275:L365-71
Ortiz, L A; Lasky, J; Hamilton Jr, R F et al. (1998) Expression of TNF and the necessity of TNF receptors in bleomycin-induced lung injury in mice. Exp Lung Res 24:721-43
Ortiz, L A; Moroz, K; Liu, J Y et al. (1998) Alveolar macrophage apoptosis and TNF-alpha, but not p53, expression correlate with murine response to bleomycin. Am J Physiol 275:L1208-18