Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08HL003575-01
Application #
2211819
Study Section
Special Emphasis Panel (ZHL1-CSR-Y (M1))
Project Start
1996-09-05
Project End
2001-07-31
Budget Start
1996-09-05
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Snyder, Peter M; Steines, Jennifer C; Olson, Diane R (2004) Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference. J Biol Chem 279:5042-6
Snyder, Peter M; Olson, Diane R; Thomas, Brittany C (2002) Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel. J Biol Chem 277:5-8
Snyder, Peter M (2002) The epithelial Na+ channel: cell surface insertion and retrieval in Na+ homeostasis and hypertension. Endocr Rev 23:258-75
McDonald, Fiona J; Western, Andrea H; McNeil, John D et al. (2002) Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel. Am J Physiol Renal Physiol 283:F431-6
Snyder, P M; Olson, D R; McDonald, F J et al. (2001) Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4. J Biol Chem 276:28321-6
Askwith, C C; Benson, C J; Welsh, M J et al. (2001) DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature. Proc Natl Acad Sci U S A 98:6459-63
Snyder, P M; Bucher, D B; Olson, D R (2000) Gating induces a conformational change in the outer vestibule of ENaC. J Gen Physiol 116:781-90
Snyder, P M (2000) Liddle's syndrome mutations disrupt cAMP-mediated translocation of the epithelial Na(+) channel to the cell surface. J Clin Invest 105:45-53
Ambrosius, W T; Bloem, L J; Zhou, L et al. (1999) Genetic variants in the epithelial sodium channel in relation to aldosterone and potassium excretion and risk for hypertension. Hypertension 34:631-7
Adams, C M; Snyder, P M; Welsh, M J (1997) Interactions between subunits of the human epithelial sodium channel. J Biol Chem 272:27295-300