This project will prepare the candidate, Dr. Aruna Pradhan, for a career as an independent clinical scientist in cardiovascular epidemiology with a focus on risk assessment of peripheral arterial disease (PAD), her area of scientific interest. At the time of award activation, Dr. Pradhan will be a board eligible cardiologist having completed her fellowship training at the Brigham and Women's Hospital (BWH), Boston. Her post-doctoral research activities have been undertaken in the Center for Cardiovascular Disease Prevention within the Division of Preventive Medicine, BWH. The Center provides a scientifically productive environment for the support of junior investigators in the conduct of population-based epidemiologic research. The applicant proposes a 5-year program of research that will prospectively evaluate novel and traditional risk factors for PAD in women, among whom limited epidemiologic data exist. The risk factors to be examined may be categorized into one of three groups: novel biomarkers, traditional and behavioral cardiovascular risk factors, and dietary influences. Employing a prospective cohort design, analyses will be conducted in the Women's Health Study of 39,876 healthy middle-aged American women. The long-term follow-up and high- quality covariate data in this cohort offer a unique opportunity to study, in a prospective manner, potentially modifiable risk factors for PAD in a large well-characterized population of women. At the conclusion of the award period, Dr. Pradhan will have acquired advanced epidemiologic skills and expertise in the study of PAD which will enable her to independently conduct research in prevention and treatment of this disease. This proposal seeks to evaluate the association between a broad range of emerging and traditional risk factors and the development of atherosclerosis in the lower extremity arterial system among American women. While prior limited data are available pertaining to these risk factors in men, information with regard to risk factor relationships in women are extremely sparse. Specific exposures of interest include blood- based biomarkers, traditional cardiovascular risk factors such as diabetes, obesity, and elevated blood pressure, behavioral risk factors such as smoking and physical inactivity, and dietary influences such as fat, antioxidant, and carbohydrate intake.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL082740-04
Application #
7577591
Study Section
Special Emphasis Panel (ZHL1-CSR-B (O1))
Program Officer
Ni, Hanyu
Project Start
2006-03-20
Project End
2011-02-28
Budget Start
2009-03-01
Budget End
2010-02-28
Support Year
4
Fiscal Year
2009
Total Cost
$136,350
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Conen, David; Everett, Brendan M; Kurth, Tobias et al. (2011) Smoking, smoking cessation, [corrected] and risk for symptomatic peripheral artery disease in women: a cohort study. Ann Intern Med 154:719-26
Ho, Deborah Y; Cook, Nancy R; Britton, Kathryn A et al. (2011) High-molecular-weight and total adiponectin levels and incident symptomatic peripheral artery disease in women: a prospective investigation. Circulation 124:2303-11
Powell, Tiffany M; Glynn, Robert J; Buring, Julie E et al. (2011) The relative importance of systolic versus diastolic blood pressure control and incident symptomatic peripheral artery disease in women. Vasc Med 16:239-46
Mora, Samia; Otvos, James D; Rosenson, Robert S et al. (2010) Lipoprotein particle size and concentration by nuclear magnetic resonance and incident type 2 diabetes in women. Diabetes 59:1153-60
Conen, David; Rexrode, Kathryn M; Creager, Mark A et al. (2009) Metabolic syndrome, inflammation, and risk of symptomatic peripheral artery disease in women: a prospective study. Circulation 120:1041-7
Neilan, Tomas G; Pradhan, Aruna D; King, Mary Etta et al. (2009) Derivation of a size-independent variable for scaling of cardiac dimensions in a normal paediatric population. Eur J Echocardiogr 10:50-5
Goulart, Alessandra C; Zee, Robert Y L; Pradhan, Aruna et al. (2009) Associations of the estrogen receptors 1 and 2 gene polymorphisms with the metabolic syndrome in women. Metab Syndr Relat Disord 7:111-7
Neilan, Tomas G; Pradhan, Aruna D; Weyman, Arthur E (2008) Derivation of a size-independent variable for scaling of cardiac dimensions in a normal adult population. J Am Soc Echocardiogr 21:779-85
Morrow, David A; Wang, Yunmei; Croce, Kevin et al. (2008) Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial Am Heart J 155:49-55
Pradhan, Aruna D; Shrivastava, Sanjay; Cook, Nancy R et al. (2008) Symptomatic peripheral arterial disease in women: nontraditional biomarkers of elevated risk. Circulation 117:823-31