Dr. Landrigan is an Instructor of Pediatrics at Harvard Medical School and an Assistant in Medicine at Children's Hospital, Boston. Following a pediatric residency, he completed fellowship training in health services research and a Master's in Public Health. He currently supervises a general pediatric service for 3-4 months per year. The remainder of the time, he pursues health services research in the quality of inpatient care. His principal areas of interest are medical error and housestaff working conditions. He is a project leader on an AHRQ-funded study, """"""""Effects of Extended Work Hours on ICU Patient Safety."""""""" Dr. Landrigan's immediate goal is to develop expertise in the impact of sleep deprivation and night work on patient safety. He has a background in health services research and the study of medication errors, but requires further training in sleep physiology, patient safety, and human factors engineering to optimally understand the interaction of sleep deprivation with error. He will take formal courses in sleep and circadian physiology, will continue training in patient safety at the Center for Patient Safety at the Brigham and Women's Hospital, and will pursue advanced training in human factors engineering. He will receive intensive mentoring by Drs. Charles A. Czeisler and Donald A. Goldmann, national leaders in sleep deprivation and health services research, respectively. His long-term career goals are 1) to become a national leader in the study of sleep deprivation, human factors, and medical error; and 2) to implement and evaluate strategies to improve working conditions and patient safety. Dr. Landrigan's research proposal is to study the manner in which interns' work schedules and sleep deprivation impact patient safety. Using a comprehensive, prospective error detection approach along with state-of-the-art technologies for the measurement of sleep, Dr. Landrigan will quantify the roles of time of day, time on duty, and sleep inertia in medical error. This study will substantially add to the understanding of sleep and patient safety by identifying the relative contributions of each of these factors, which will be important for the development of appropriate fatigue and error countermeasures. The results of this research may have significant implications for the traditional call schedules of medical trainees and the organization of hospital care at night.

National Institute of Health (NIH)
Agency for Healthcare Research and Quality (AHRQ)
Clinical Investigator Award (CIA) (K08)
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HSR Health Care Research Training SS (HCRT)
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Anderson, Kay
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Children's Hospital Boston
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Czeisler, Charles A; Pellegrini, Carlos A; Sade, Robert M (2013) Should sleep-deprived surgeons be prohibited from operating without patients' consent? Ann Thorac Surg 95:757-66
Czeisler, Charles A (2009) Medical and genetic differences in the adverse impact of sleep loss on performance: ethical considerations for the medical profession. Trans Am Clin Climatol Assoc 120:249-85
Fahrenkopf, Amy M; Sectish, Theodore C; Barger, Laura K et al. (2008) Rates of medication errors among depressed and burnt out residents: prospective cohort study. BMJ 336:488-91
Landrigan, Christopher P; Fahrenkopf, Amy M; Lewin, Daniel et al. (2008) Effects of the accreditation council for graduate medical education duty hour limits on sleep, work hours, and safety. Pediatrics 122:250-8
Landrigan, Christopher P; Czeisler, Charles A; Barger, Laura K et al. (2007) Effective implementation of work-hour limits and systemic improvements. Jt Comm J Qual Patient Saf 33:19-29
Srivastava, Rajendu; Landrigan, Christopher P; Ross-Degnan, Dennis et al. (2007) Impact of a hospitalist system on length of stay and cost for children with common conditions. Pediatrics 120:267-74
Landrigan, Christopher P; Barger, Laura K; Cade, Brian E et al. (2006) Interns' compliance with accreditation council for graduate medical education work-hour limits. JAMA 296:1063-70
Lockley, Steven W; Landrigan, Christopher P; Barger, Laura K et al. (2006) When policy meets physiology: the challenge of reducing resident work hours. Clin Orthop Relat Res 449:116-27
Walsh, Kathleen E; Adams, William G; Bauchner, Howard et al. (2006) Medication errors related to computerized order entry for children. Pediatrics 118:1872-9
Rothschild, Jeffrey M; Landrigan, Christopher P; Cronin, John W et al. (2005) The Critical Care Safety Study: The incidence and nature of adverse events and serious medical errors in intensive care. Crit Care Med 33:1694-700

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