The overall aim of this application is to enhance the applicant's skills in clinical research through a program combining education, mentoring, and the completion of a controlled clinical trial. The objective of the controlled trial is to compare the outcome of adolescent patients with anorexia nervosa (AN) treated with intensive outpatient family therapy designed to reduce hospitalization, compared to a comparison group of adolescents with AN who receive less intensive outpatient family therapy. The intention is to test the effectiveness of intensive outpatient management as a potential alternative to hospitalization, to investigate factors predicting outcome, and provide information about the relative cost-effectiveness of more intensive compared to less intensive care. The candidate s major goal is to develop his research capacities in clinical child psychiatry with a focus on the populations treated in a clinical pediatric psychiatry program. At the end of the award period, the candidate expects to 1) possess the skills necessary to be an independent investigator in the mental health of children; 2) to have received funding as an independent investigator; and 3) to become a leader in the scientific study of patients with illnesses on the interface of pediatrics and psychiatry. The research focus of this application is on outcome and service-related issues in adolescents with AN. The candidate s broad career goal is to integrate clinical research on outcomes and service research into ongoing clinical and administrative activities in this area. In addition to the research activity, the candidate will participate in graduate course work in the School of Medicine s Department of Health Care Policy and Research and the Department of Psychiatry in the ethical conduct of research and the economics of health care. He will also take courses in the Departments of Psychology, Statistics, and Education at Stanford University in statistical and research methods related to behavioral sciences research. He will also participate in seminars and tutorials with identified educational consultants in areas related to his planned research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08MH001457-03
Application #
6185588
Study Section
Special Emphasis Panel (ZMH1-BRB-S (03))
Program Officer
Hibbs, Euthymia D
Project Start
1998-09-01
Project End
2003-07-31
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
3
Fiscal Year
2000
Total Cost
$154,798
Indirect Cost
Name
Stanford University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Loeb, Katharine L; Lock, James; Grange, Daniel le et al. (2012) Transdiagnostic Theory and Application of Family-Based Treatment for Youth with Eating Disorders. Cogn Behav Pract 19:17-30
Le Grange, Daniel; Hoste, Renee Rienecke; Lock, James et al. (2011) Parental expressed emotion of adolescents with anorexia nervosa: outcome in family-based treatment. Int J Eat Disord 44:731-4
Lee, Huei-Yen; Lock, James (2007) Anorexia nervosa in Asian-American adolescents: do they differ from their non-Asian peers. Int J Eat Disord 40:227-31
Pereira, Tintina; Lock, James; Oggins, Jean (2006) Role of therapeutic alliance in family therapy for adolescent anorexia nervosa. Int J Eat Disord 39:677-84
Couturier, Jennifer; Lock, James (2006) What is recovery in adolescent anorexia nervosa? Int J Eat Disord 39:550-5
Lock, James; Couturier, Jennifer; Bryson, Susan et al. (2006) Predictors of dropout and remission in family therapy for adolescent anorexia nervosa in a randomized clinical trial. Int J Eat Disord 39:639-47
Lock, James; Couturier, Jennifer; Agras, W Stewart (2006) Comparison of long-term outcomes in adolescents with anorexia nervosa treated with family therapy. J Am Acad Child Adolesc Psychiatry 45:666-72
Lock, James; Agras, W Stewart; Bryson, Susan et al. (2005) A comparison of short- and long-term family therapy for adolescent anorexia nervosa. J Am Acad Child Adolesc Psychiatry 44:632-9
Passi, Vandana A; Bryson, Susan W; Lock, James (2003) Assessment of eating disorders in adolescents with anorexia nervosa: self-report questionnaire versus interview. Int J Eat Disord 33:45-54
Le Grange, Daniel; Lock, James; Dymek, Maureen (2003) Family-based therapy for adolescents with bulimia nervosa. Am J Psychother 57:237-51

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