This is a revised application for a Mentored Clinical Scientist Development Award (K08). The candidate proposes a combination of didactics, individual meetings with mentors and consultants, and the implementation of a research study to develop an expertise in neurodevelopmental models of functional and effective connectivity. The purpose of this training grant is to obtain the skills and experience necessary to become competent in statistical models to study connectivity in fMRI and diffusion tensor imaging (DTI) and to develop the skills to integrate these imaging modalities. The models will include the initial use of exploratory multivariate techniques, followed by structural equation modeling. These models will be used to study typical neurodevelopment from late childhood through adolescence and schizophrenia in children and adolescents. The candidate has a background in electrical engineering and clinical training in the phenomenology of schizophrenia and structural brain imaging. However, her focus in engineering was in the design of analog electronic circuits for bioengineering applications and she requires retooling in digital signal processing and statistical paradigms to measure functional and effective connectivity. She is also proposing additional training in neuroanatomy and cognitive developmental neuroscience related to the prefrontal cortex and its connections with other brain regions. This training will be integrated into a neurodevelopmental study of the functional connectivity and microstructure of nodes involved in a spatial working memory circuit. The study will involve imaging (fMRI and DTI) first in two groups (n=15) of typically developing children (10- 12 y.o.) and young adults (18-19 y.o.), then in patients with schizophrenia (n=36) compared to a matched sample who are between the ages of 10 and 19. The candidate has an organized program of training that includes coursework in imaging, digital signal processing, statistics, neuroanatomy, cognitive developmental neuroscience, and the bioethics of research. She will meet regularly with her sponsor and consultants, who have a track record of excellence in research and will assist with her training and career development. She has also set forth a timeline for the completion of the projects. Her long term goals are to use the inherent plasticity of the brain to study intervention strategies that bring about a protective 'rewiring' in children at risk. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08MH068540-04
Application #
7238577
Study Section
Special Emphasis Panel (ZRG1-CNNT (02))
Program Officer
Wagner, Ann
Project Start
2004-06-01
Project End
2009-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
4
Fiscal Year
2007
Total Cost
$179,121
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Psychiatry
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Kong, Xiang-Zhen; Mathias, Samuel R; Guadalupe, Tulio et al. (2018) Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci U S A 115:E5154-E5163
Walton, Esther; Hass, Johanna; Liu, Jingyu et al. (2016) Correspondence of DNA Methylation Between Blood and Brain Tissue and Its Application to Schizophrenia Research. Schizophr Bull 42:406-14
Chavarria-Siles, Ivan; White, Tonya; de Leeuw, Christiaan et al. (2016) Myelination-related genes are associated with decreased white matter integrity in schizophrenia. Eur J Hum Genet 24:381-6
White, Tonya; Mous, Sabine; Karatekin, Canan (2014) Memory-guided saccades in youth-onset psychosis and attention deficit hyperactivity disorder (ADHD). Early Interv Psychiatry 8:229-39
Mous, Sabine E; Karatekin, Canan; Kao, Chiu-Yen et al. (2014) Gyrification differences in children and adolescents with velocardiofacial syndrome and attention-deficit/hyperactivity disorder: a pilot study. Psychiatry Res 221:169-71
Ehrlich, Stefan; Geisler, Daniel; Yendiki, Anastasia et al. (2014) Associations of white matter integrity and cortical thickness in patients with schizophrenia and healthy controls. Schizophr Bull 40:665-74
Walton, Esther; Liu, Jingyu; Hass, Johanna et al. (2014) MB-COMT promoter DNA methylation is associated with working-memory processing in schizophrenia patients and healthy controls. Epigenetics 9:1101-7
van den Bosch, Gerbrich E; El Marroun, Hanan; Schmidt, Marcus N et al. (2014) Brain connectivity during verbal working memory in children and adolescents. Hum Brain Mapp 35:698-711
Su, Shu; White, Tonya; Schmidt, Marcus et al. (2013) Geometric computation of human gyrification indexes from magnetic resonance images. Hum Brain Mapp 34:1230-44
Gollub, Randy L; Shoemaker, Jody M; King, Margaret D et al. (2013) The MCIC collection: a shared repository of multi-modal, multi-site brain image data from a clinical investigation of schizophrenia. Neuroinformatics 11:367-88

Showing the most recent 10 out of 34 publications