The majority of Americans report exposure to a traumatic event, although only a minority develops posttraumatic stress disorder (PTSD). The disparity between the prevalence of exposure and the development of PTSD has driven epidemiologic research to determine the etiology of PTSD and to identify the factors that increase risk for the disorder. To date, most research has only identified correlates of PTSD, not true risk factors. Furthermore, few epidemiologic studies have tested models based on research from neurocognitive studies of PTSD or taken into account genetic influences on the disorder. Thus, progress in PTSD risk factor research has been limited methodologically and conceptually, suffering from a lack of integration with findings from other research domains, such as cognitive neuroscience and behavioral genetics. The purpose of this Mentored Clinical Scientist Development Award (K08) is to enable the candidate, a clinical psychologist with recent postdoctoral training in psychiatric epidemiology, to become an independent investigator conducting integrative research on the developmental epidemiology of PTSD. The research component of this proposal focuses on developing and testing a specific etiologic model: that neurocognitive self-regulation is a central mechanism underlying the relationship between genetic and environmental risk factors identified in epidemiologic studies and PTSD. To test this model, the candidate will obtain training in developmental psychopathology informed by cognitive neuroscience and behavioral genetics. Training will be provided via coursework, formal tutorials and consultation with a panel of experts, conferences, literature reviews, and specific research projects. Research projects include: 1) two major longitudinal, epidemiologic studies of developmental psychopathology, 2) a family-based candidate gene association study, and 3) a pilot case-control study of markers for neurocognitive self regulation in PTSD. Training obtained via this award will prepare the candidate to submit an R01 application for a longitudinal genetically informative study of the role of neurocognitive self-regulation in the development of PTSD. This work will help the development of prevention and treatment interventions for traumatized individuals and will contribute to our understanding of the etiology of PTSD.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Clinical Investigator Award (CIA) (K08)
Project #
Application #
Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Boyce, Cheryl A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Harvard University
Social Sciences
Schools of Public Health
United States
Zip Code
Paradis, Angela D; Koenen, Karestan C; Fitzmaurice, Garrett M et al. (2016) Impact of persistent and adolescent-limited antisocial behaviour on adult health outcomes. J Epidemiol Community Health 70:1004-10
Paradis, Angela D; Fitzmaurice, Garrett M; Koenen, Karestan C et al. (2015) A prospective investigation of neurodevelopmental risk factors for adult antisocial behavior combining official arrest records and self-reports. J Psychiatr Res 68:363-70
Demmer, Ryan T; Gelb, Sara; Suglia, Shakira F et al. (2015) Sex differences in the association between depression, anxiety, and type 2 diabetes mellitus. Psychosom Med 77:467-77
Keyes, Katherine M; McLaughlin, Katie A; Demmer, Ryan T et al. (2013) Potentially traumatic events and the risk of six physical health conditions in a population-based sample. Depress Anxiety 30:451-60
Roberts, Andrea L; Dohrenwend, Bruce P; Aiello, Allison E et al. (2012) The stressor criterion for posttraumatic stress disorder: does it matter? J Clin Psychiatry 73:e264-70
McLaughlin, K A; Nandi, A; Keyes, K M et al. (2012) Home foreclosure and risk of psychiatric morbidity during the recent financial crisis. Psychol Med 42:1441-8
Roberts, Andrea L; Galea, Sandro; Austin, S Bryn et al. (2012) Posttraumatic stress disorder across two generations: concordance and mechanisms in a population-based sample. Biol Psychiatry 72:505-11
Roberts, Andrea L; Rosario, Margaret; Corliss, Heather L et al. (2012) Elevated risk of posttraumatic stress in sexual minority youths: mediation by childhood abuse and gender nonconformity. Am J Public Health 102:1587-93
Roberts, Andrea L; Rosario, Margaret; Corliss, Heather L et al. (2012) Childhood gender nonconformity: a risk indicator for childhood abuse and posttraumatic stress in youth. Pediatrics 129:410-7
Keyes, Katherine M; McLaughlin, Katie A; Koenen, Karestan C et al. (2012) Child maltreatment increases sensitivity to adverse social contexts: neighborhood physical disorder and incident binge drinking in Detroit. Drug Alcohol Depend 122:77-85

Showing the most recent 10 out of 77 publications