Dr. Glaser is a dedicated physician/scientist who is strongly committed to a career as an academic physician. He is currently an Assistant Professor on a tenure-track at the University of Kentucky. His scientific goal is to understand the neurobiology of Attention-Deficit/Hyperactivity Disorder (ADHD) and its treatments. With his joint appointments in Psychiatry and Anatomy & Neurobiology, he will be receiving laboratory and resource support from both departments. During the entire award period Dr. Glaser will be spending 75% of his time with laboratory related activities. In addition to research, he will be spending 15% of his time pursuing clinical activities, primarily in the areas of Child Psychiatry and Pediatrics in the treatment of children and adults with symptoms of ADHD. 10% of his time will be devoted to the teaching of residents and students, as well as educational activities. His sponsor, Dr. Gerhardt, is a leader in the field of neuropsychopharmacology of dopamine modulating medications as well as a recent co-collaborator in the field of ADHD. The neuroscience community at the University of Kentucky will also provide a rich source for collaboration and intellectual support. Additional support will be provided by co-sponsor Dr. F. Xavier Castellanos at NYU, a leader in translational ADHD research. The primary goal of Dr. Glaser's proposal is to investigate physiologically-relevant differences in dopaminergic activity evoked by different isomers of amphetamine found in clinically prescribed medications for ADHD using a novel combination of voltammetric and microdialysis in the mouse striatum and nucleus accumbens. A secondary goal is to investigate the possible contribution that dopamine D4 receptors (D4R) may have to dopaminergic function in the mouse. Dr. Glaser will utilize mice designed by Dr. Grandy at the Oregon Health Sciences University that are missing the D4R (D4R knockout mice) to specifically investigate differences in their baseline behavior and stimulant induced behaviors. The integrated training, mentorship, research, and teaching of Dr. Glaser provided by this award will allow him to develop as an independent investigator dedicated to using basic neuroscience to solve important problems which physicians face everyday in the treatment of children and adults with ADHD and potentially will lead to better understanding and superior treatments for ADHD, thus reducing its burden on today's schools, health systems, and society.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08MH070840-04
Application #
7197993
Study Section
Neurobiology of Motivated Behavior Study Section (NMB)
Program Officer
Chavez, Mark
Project Start
2004-04-01
Project End
2009-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
4
Fiscal Year
2007
Total Cost
$166,632
Indirect Cost
Name
University of Kentucky
Department
Psychiatry
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Miller, Erin M; Quintero, Jorge E; Pomerleau, Fran├žois et al. (2015) Simultaneous glutamate recordings in the frontal cortex network with multisite biomorphic microelectrodes: New tools for ADHD research. J Neurosci Methods 252:75-9
Miller, Erin M; Pomerleau, Francois; Huettl, Peter et al. (2012) The spontaneously hypertensive and Wistar Kyoto rat models of ADHD exhibit sub-regional differences in dopamine release and uptake in the striatum and nucleus accumbens. Neuropharmacology 63:1327-34
Thomas, Theresa Currier; Kruzich, Paul J; Joyce, B Matthew et al. (2007) Dopamine D4 receptor knockout mice exhibit neurochemical changes consistent with decreased dopamine release. J Neurosci Methods 166:306-14
Joyce, B Matthew; Glaser, Paul E A; Gerhardt, Greg A (2007) Adderall produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers. Psychopharmacology (Berl) 191:669-77