This application describes a 5 year mentored training program to develop a research career in Child and Adolescent Psychiatry focused on improving phenotypic approaches to defining pediatric bipolar disorder. The principal investigator has completed M.D., Ph.D. and residency training in child and adolescent psychiatry. He will now gain expertise in taxonomic approaches, multi-informant assessment, family and twin designs, and latent variable models. As primary sponsor, Dr. James Hudziak will mentor the Pi's scientific development. Dr. Hudziak is an expert in taxonomic approaches using family study and twin study behavioral genetic designs in concert with latent variable measures to developmental psychopathology. The training program will enlist the co-sponsorship of Dr. Dorret Boomsma, Professor at the Vrije University of Amsterdam and internationally known expert on twin studies and Dr. Thomas Achenbach, Professor at the University, of Vermont. In addition, three internationally-renowned scientists, Drs. Frank Verhulst, Ellen Leibenluft and Michael Neale will provide scientific consultation. Research will focus on diagnostic approaches to children often diagnosed as having pediatric bipolar disorder and related severe dysregulation in affect, behavior and cognition. The training and research will emphasize the use of categorical DSM-based approaches and compare them to quantitative CBCL- based approaches. The proposed studies will combine and contrast DSM and quantitative measures in order to advance the understanding of highly troubled youth. New to this application are proposed research projects allowing for testing of the relations between DSM and quantitative measures, the familiality of DSM and quantitative definitions, the overlap between the approaches, and the construct validity of CBCL-based phenotyping in longitudinal, genetically informative designs. The long term goal of this research is to develop more refined phenotypic approaches for children with severe problems in dysregulation who may or may not meet narrowly defined DSM criteria for pediatric bipolar disorder. If realized, these approaches can then be used in genetic, neuroimaging, and treatment studies aimed at reducing the burden of suffering that children and families with these disorders endure.
By characterizing children with profound problems with attention, mood swings, and aggression I hope to identify modifiable genetic and environmental factors to reduce depression, personality disorders and substance use in adolescence and adulthood. I hope to add perspective on children who are called """"""""bipolar"""""""" but who likely have a disorder different from adult bipolar disorder and may need different treatments.
| Basten, Maartje; Tiemeier, Henning; Althoff, Robert R et al. (2016) The Stability of Problem Behavior Across the Preschool Years: An Empirical Approach in the General Population. J Abnorm Child Psychol 44:393-404 |
| Spechler, Philip A; Orr, Catherine A; Chaarani, Bader et al. (2015) Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat. Dev Cogn Neurosci 16:63-70 |
| Savage, Jeanne; Verhulst, Brad; Copeland, William et al. (2015) A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms. J Am Acad Child Adolesc Psychiatry 54:377-84 |
| Baer, Julie; Schreck, Meghan; Althoff, Robert R et al. (2015) Child Temperament, Maternal Parenting Behavior, and Child Social Functioning. J Child Fam Stud 24:1152-1162 |
| Crehan, Eileen T; Althoff, Robert R (2015) Measuring the stare-in-the-crowd effect: a new paradigm to study social perception. Behav Res Methods 47:994-1003 |
| Whelan, Robert; Watts, Richard; Orr, Catherine A et al. (2014) Neuropsychosocial profiles of current and future adolescent alcohol misusers. Nature 512:185-9 |
| Basten, Maartje; van der Ende, Jan; Tiemeier, Henning et al. (2014) Nonverbal intelligence in young children with dysregulation: the Generation R Study. Eur Child Adolesc Psychiatry 23:1061-70 |
| Althoff, Robert R; Kuny-Slock, Ana V; Verhulst, Frank C et al. (2014) Classes of oppositional-defiant behavior: concurrent and predictive validity. J Child Psychol Psychiatry 55:1162-71 |
| Basten, Maartje M G J; Althoff, Robert R; Tiemeier, Henning et al. (2013) The dysregulation profile in young children: empirically defined classes in the Generation R study. J Am Acad Child Adolesc Psychiatry 52:841-850.e2 |
| Rubin, David H; Althoff, Robert R; Ehli, Erik A et al. (2013) Candidate gene associations with withdrawn behavior. J Child Psychol Psychiatry 54:1337-45 |
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