Abstract

Angiotensin II when injected into brain induces sodium and water homeostatic states that are similar to those found in head injured patients. The enzymatic pathway for the generation of angiotensin II within brain tissue may be linked to a novel angiotensin- specific carboxypeptidase identified by the PI. This proposal will permit the isolation of angiotensin specific carboxypeptidase. Polyclonal antibodies will permit the subsequent cellular localization.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08NS001164-01A1
Application #
3083923
Study Section
Neurological Disorders Program Project Review A Committee (NSPA)
Project Start
1988-02-01
Project End
1993-01-31
Budget Start
1988-02-01
Budget End
1989-01-31
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Louisville
Department
Type
Schools of Medicine
DUNS #
City
Louisville
State
KY
Country
United States
Zip Code
40292

  Publications

Chen, J; Van Veen, B D; Hecox, K E (1995) A spatial feature extraction and regularization model for the head-related transfer function. J Acoust Soc Am 97:439-52
Chen, J; Van Veen, B D; Hecox, K E (1992) External ear transfer function modeling: a beamforming approach. J Acoust Soc Am 92:1933-44
Miller, J J; Changaris, D G; Levy, R S (1991) Angiotensin carboxypeptidase activity in urine from normal subjects and patients with kidney damage. Life Sci 48:1529-35